Local Anesthetics New Formulations: From Development to Clinical Tests

University of Campinas, Brazil1 site in 1 country32 target enrollmentJuly 2008

ConditionsDental Anesthesia Efficacy

InterventionsPrilocaine

DrugsPrilocaine

Overview

Phase: Phase 1
Intervention: Prilocaine
Conditions: Dental Anesthesia Efficacy
Sponsor: University of Campinas, Brazil
Enrollment: 32
Locations: 1
Primary Endpoint: Anesthesia success, onset and duration of pulpal and gingival anesthesia.
Status: Completed
Last Updated: 16 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

This blinded randomized, crossover, three period study aim to evaluate the anesthetic efficacy of liposome-encapsulated 3% prilocaine compared to 3% plain prilocaine and 3% prilocaine with 0,03IU/mL felypressin, after 1.8mL infiltration in the buccal sulcus of the maxillary right canine, in 32 volunteers.

Registry

clinicaltrials.gov

Start Date

July 2008

End Date

November 2009

Last Updated

16 years ago

Study Type

Interventional

Study Design

Crossover

Sex

All

Investigators

Sponsor

University of Campinas, Brazil

Eligibility Criteria

Inclusion Criteria

•good health
•no history of allergy to the components of the local anesthetic formulations tested
•maxillary canine, lateral incisor, and first premolar responsible to electric stimulation

Exclusion Criteria

•intake of any medication that would alter pain perception
•history of trauma or sensitivity, caries, restorations, periodontal disease and endodontic treatment in the maxillary canine, lateral incisor, and first premolar
•systemic disease