Radiological and immunological effects of COVID-19 infection on the central nervous system

Not Applicable

Recruiting

Conditions: COVID-19

Registration Number: DRKS00023880

Lead Sponsor: niversitätsklinikum FrankfurtInstitut für Neuroradiologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 170

Inclusion Criteria

• Nose and / or throat swab with PCR positive result for SARS-CoV-2
• Recovered for at least 3 months at the time of the MRI measurement
• Ability to give consent

• Nose and / or throat swab with negative PCR result for SARS-CoV-2
• Negative antibody test
• Ability to give consent

Exclusion Criteria

- Pregnancy and breast feeding period
- Exclusion criteria for an MRT examination: Ferromagnetic metals in the body (containing iron, nickel, cobalt; implants; cardiac defibrillator, pacemaker)

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Standard 3D FLAIR measurement for the detection of visible brain lesions<br>2. Quantitative MRI with T1 mapping, B1 mapping, DTI, and T2 mapping<br><br>Evaluation:<br>• Visually recognizable damage in the FLAIR (e.g. post-ischemic, post-infectious)<br>• T1 relaxation values ??and T2 relaxation values ??with histograms of the gray and white brain matter and ROI-based measurement of the brain stem, the entorhinal cortex (first connection of the olfactory nerve) and the limbic system<br>• DTI with measurement of FA and mean diffusivity in the white matter of the brain and ROI-based in the brain stem, in the entorhinal cortex and in the limbic system

Secondary Outcome Measures

Name	Time	Method
Analysis of CSF and serum parameters of recovered COVID-19 patients and a control collective of subjects that had not contracted COVID-19.<br>Detection of focal neurological or cognitive deficits after a previous SARS-CoV-2 infection.<br>Recording of central respiratory disorder in patients after COVID-19.