Exercising the Motor Cortex Using Brain Stimulation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Change in Motor Evoked Potentials (MEPs) across time points
研究概览
简要总结
The research project explores how non-invasive brain stimulation can be used to detect and ameliorate loss of muscle strength after inactivity. At present, there is a limited understanding of how to maintain muscle strength during inactivity. Increasing evidence indicates that reduction in muscle strength following immobilisation is associated with reduced cortical motor output. Therefore, the aim of the study is to test if brain stimulation, can maintain cortical motor output and ameliorate the loss of muscle strength following immobilisation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •right-handed
- •aged 18-30
- •healthy BMI
排除标准
- •no primary muscle disorders
- •no open wounds or skin conditions to arms and hands
- •no neurological disorders or history of
- •no history of fainting/convulsions
- •no metal implanted into head/eye/neck
- •non-smoker
- •no arm, hand, fingers, shoulder injuries
结局指标
主要结局
Change in Motor Evoked Potentials (MEPs) across time points
时间窗: 0, 24, 48, and 72 hours
MEPs are elicited via TMS to primary motor cortex and index the excitability of the motor pathway. They are recorded non-invasively from muscles using surface electrodes. At each time point of the study (0, 24, 48, 72 hours) record MEPs will be recorded pre and post-intervention from the hand muscles of the dominant (immobilised) arm, and non-dominant (non-immobilised arm), to evaluate changes in excitability. Specifically, the peak-to-peak value of the MEPs from the hand will be measured, which reflects the amplitude of the MEP response. The latency of the MEP to index neural conduction speed will also be measured.
次要结局
- Change in grip strength across time points(0, and 72 hours.)
研究者
Helen Nuttall
Lecturer in Cognitive Neuroscience
Lancaster University