Effect of Oral Zinc Sulfate Supplementation on Enzymes of Urate Pathway

Not Applicable

Completed

• Conditions: Infertility Unexplained

• Registration Number: NCT03361618
• Lead Sponsor: Babylon University

Brief Summary

Although many reports have investigated the relationship between subfertility and uric acid levels in semen, to the best of author knowledge, there is no study have been published to yet focus on the effects of asthenospermia treatments, such as given an oral zinc supplementation, on the activity of urate-related enzymes, which are important in fertility of human.

Detailed Description

The present study was designed to investigate the effect of zinc supplementation on the qualitative and quantitative characteristics of semen, along with uric acid levels and urate-related enzymes in the seminal plasma and spermatozoa of asthenospermic males.

Study Timeline

• Study Start: 2011-07-01
• Primary Completion: 2012-06-01
• Study Completion: 2012-06-01
• Study First Submitted: 2017-11-07
• Status Verified: 2017-12
• Study First Submitted QC: 2017-12-04
• Last Update Submitted: 2017-12-04
• Study First Posted: 2017-12-05
• Last Update Posted: 2017-12-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 120

Inclusion Criteria

• The presence of asthenozoospermia in the semen sample.
• Must be unable to reproduce.

Exclusion Criteria

• the absence of endocrinopathy, varicocele, and female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Measurement the uric acid level in spermatozoa and seminal plasma by using spectrophotometer.	up to three months.	Clinical parameter

Secondary Outcome Measures

Name	Time	Method
Measurement the adenosine deaminase activity in spermatozoa and seminal plasma by using spectrophotometer.	up to three months.	Enzyme
Measurement the 5'-nucleotidase activity in spermatozoa and seminal plasmaby using the spectrophotometer.	up to three months.	Enzyme
Measurement the xanthine oxidase activity in spermatozoa and seminal plasma by using spectrophotometer.	up to three months.	Enzyme

Trial Locations

Locations (1)

Mahmoud Hussein Hadwan; 🇮🇶 Hilla, Babylon, Iraq