The Effect of Oral Zinc Supplementation on Thiol Oxido-reductive Index
Phase 2
Completed
- Conditions
- Asthenozoospermia
- Registration Number
- NCT02985905
- Lead Sponsor
- mahmoud hussein hadwan
- Brief Summary
Although several studies have considered the relationship between infertility and semen thiol compounds levels, no study on the effects of asthenospermia treatments such as oral zinc supplementation on thiol related enzymes activity which are important in fertility of the individual has been reported.
- Detailed Description
The present study was conducted to study the effect of zinc supplementation on the quantitative and qualitative characteristics of semen along with reduced thiol, oxidized thiol and thiol related enzymes in the seminal plasma of asthenospermic patients.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 120
Inclusion Criteria
- The presence of asthenozoospermia in the semen sample.
Exclusion Criteria
- The absence of endocrinopathy, varicocele, and female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Thiol oxido-reductive index levels in spermatozoa and seminal plasma. The investigators evaluated the effects of zinc sulfate (220 mg/d) supplementation on Thiol oxido-reductive index levels. up to three months.
- Secondary Outcome Measures
Name Time Method Glutathione peroxidase activity levels in spermatozoa and seminal plasma. The investigators evaluated the effects of zinc sulfate (220 mg/d) supplementation on Glutathione peroxidase activity levels. up to three months. Sulfhydryl oxidase activity levels in spermatozoa and seminal plasma. The investigators evaluated the effects of zinc sulfate (220 mg/d) supplementation on Sulfhydryl oxidase activity levels. up to three months.
Trial Locations
- Locations (1)
Mahmoud Hadwan
🇮🇶Hilla, Babylon, Iraq
Mahmoud Hadwan🇮🇶Hilla, Babylon, Iraq