Weight Loss and Cognitive Function in Middle-Aged and Older Adults
Overview
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 33
- Locations
- 1
- Primary Endpoint
- Cognitive function changes - attention
Overview
Brief Summary
More than two-thirds of middle-aged and older adults are overweight, which places them at greater risk of disability and higher medical expenses. Lifestyle interventions which promote weight loss for this population are needed. However, it is not known how different weight loss approaches impact brain (cognitive) functions, such as memory and attention. The investigator's investigation aims to improve adherence to a hypocaloric diet prescription through improved attention and inhibitory control, reduced hunger, and increased satiety.
The objectives of this pilot study are to: 1) determine the feasibility and establish proof-of-concept; 2) establish proficiency and feasibility of the proposed cognitive function assessments; and 3) obtain preliminary data for effect size generation.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 50 Years to 75 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Overweight or obese, BMI 25-40 kg/m\^2
- •Able to use a computer, keyboard, and mouse
Exclusion Criteria
- •Uncontrolled hypertension
- •Orthopedic injury
- •Other conditions that preclude participation in a walking program
- •Previous participation in psychology research which involved computerized cognitive testing
- •Diabetes which requires insulin
Outcomes
Primary Outcomes
Cognitive function changes - attention
Time Frame: 30-min measurement per session
Computerized tasks will score each participant's performance for attention at baseline and after both the 4-week weight loss and weight maintenance phases.
Cognitive function changes - inhibitory control
Time Frame: 30-min measurement per session
Computerized tasks will score each participant's performance for inhibitory control at baseline and after both the 4-week weight loss and weight maintenance phases.
Weight change
Time Frame: 5-min measurement per session
Weight will be measured on a scale at baseline and after both the 4-week weight loss and weight maintenance phases.
Secondary Outcomes
- Perceived hunger(15-minute measurement per session)
Investigators
Brenda Davy
Professor
Virginia Polytechnic Institute and State University