The Effect of Resistance Training on Proprotein Subtilisin Convertase Kexin 9 Level After Coronary Bypass Surgery

Not Applicable

Completed

Conditions: Coronary Artery Disease

Interventions: Behavioral: aerobic training
Behavioral: resistance training

Registration Number: NCT02674659

Lead Sponsor: National Cardiovascular Center Harapan Kita Hospital Indonesia

Brief Summary: This research add resistance training to patients who undergo cardiac rehabilitation program after coronary bypass surgery, comparing the level of PCSK9 level on that group to another group who receives conventional rehabilitation program (only aerobic exercise)

Detailed Description: The PCSK9 level measured before and after cardiac rehabilitation program (around 3-4 weeks), and compared between two groups. ELISA method will be used to measure plasma PCSK9 level.

Resistance training will be given by professional trainer in gymnasium of National Cardiovascular Center Harapan Kita supervised by cardiologists, following rules from American College of Sports Medicine guideline regarding to exercise after cardiac event.

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 87

Inclusion Criteria

post elective coronary artery bypass surgery
> 18 years old
sign informed consent

Exclusion Criteria

contraindications of resistance training (unstable angina, uncontrolled blood pressure (systolic > 160 mmHg diastolic > 100 mmHg), acute heart failure, pulmonary diseases, arrhythmia malignant)
musculoskeletal pain, visual analog scale >3
post congenital heart disease surgery
post elective coronary artery bypass surgery with malfunction valves (operated or not)

Study & Design

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	aerobic training	Patients after coronary bypass surgery who undergo conventional cardiac rehabilitation program (aerobic training only)
Intervention group	resistance training	Patients after coronary bypass surgery who undergo conventional cardiac rehabilitation program plus resistance training (aerobic and resistance training as well)
Intervention group	aerobic training	Patients after coronary bypass surgery who undergo conventional cardiac rehabilitation program plus resistance training (aerobic and resistance training as well)

Primary Outcome Measures

Name	Time	Method
PCSK-9 Level	3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)	this outcome measurement will be achieved by taking patient's blood sample after cardiac rehabilitation program. The method that we use to check PCSK-9 level is ELISA method

Secondary Outcome Measures

Name	Time	Method
Low Density Lipoprotein	3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)	this outcome measurement will be achieved by taking patient's blood sample after cardiac rehabilitation program
High-Density Lipoprotein	3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)	this outcome measurement will be achieved by taking patient's blood sample after cardiac rehabilitation program
Systolic Blood Pressure	3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)	this outcome measurement will be achieved by taking the patient's blood pressure after cardiac rehabilitation program
Body Mass Index	3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)	Body Mass Index is calculated by calculating the measured body weight divided by the height square in measure. We take BMI data after cardiac rehabilitation program in every participant.
Total Cholesterol	3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)	this outcome measurement will be achieved by taking patient's blood sample after cardiac rehabilitation program
Triglyceride	3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)	This outcome measurement will be achieved by taking the patient's blood sample after cardiac rehabilitation program
Fasting Blood Glucose	3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)	Blood glucose concentration was taken after 10-12-hour fasting. This outcome measurement will be achieved by taking the patient's blood sample after cardiac rehabilitation program
Diastolic Blood Pressure	3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)	this outcome measurement will be achieved by taking the patient's blood pressure after cardiac rehabilitation program