3/7 Resistance Training Method in Cardiac Rehabilitation
- Conditions
- Heart FailureCoronary Artery Disease
- Interventions
- Other: 3/7 Resistance Training MethodOther: 3X9 Resistance Training Method
- Registration Number
- NCT05696990
- Lead Sponsor
- Université Libre de Bruxelles
- Brief Summary
Aim of the clinical monocentric study is to assess the resistance training exercise intervention in patients with Heart Failure with reduced Ejection Fraction (HFrEF) and coronary artery disease that will best improve peak oxygen uptake (Peak Vo2) and leg strength (assessed Isokinetic). The investigators hypothesize that resistance training exercise with induced a high stress metabolic is more important exercise with induced than a lower stress metabolic.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 112
- Clinical Coronary artery diseases
- Heart failure with reduced ejection fraction
- angina
- acutely decompensated heart failure
- electrocardiographic evidence of ischemia
- significant valvular disease
- orthopedic/neurologic disorders that limited exercise
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 3/7 RT method 3/7 Resistance Training Method perform interval- type endurance exercise at high intensity and resistance training with the 3/7 method 3X9 RT method 3X9 Resistance Training Method perform interval- type endurance exercise at high intensity and resistance training with the 3X9 method
- Primary Outcome Measures
Name Time Method Change in Peak VO2 after 3 months Baseline and 3 months Change in Peak oxygen consumption (VO2) after three 3 months intervention
Change in strength knee extensor after 3 months Baseline and 3 months Change in strength knee extensor (60°/sec) after three months intervention
- Secondary Outcome Measures
Name Time Method Change in Body fat after 3 months Baseline and 3 months Change in Body fat at baseline and 3 months intervention
Change in leg lean mass after 3 months Baseline and 3 months Change in leg lean mass at baseline and 3 months intervention
Change in submaximal exercise capacity after 3 months Baseline and 3 months Submaximal exercise capacity will be measured using watts at the first ventilatory threshold (VT1)
Change in bone mass after 3 months Baseline and 3 months Change in bone mass at baseline and 3 months intervention
Change in 120°/sec strength knee extensor after 3 months Baseline and 3 months Change in strength knee extensor (120°/sec) at baseline and 3 months intervention
Change in lean mass after 3 months Baseline and 3 months Change in lean mass at baseline and 3 months intervention
Change in VE/VCO2 slope after 3 months Baseline and 3 months Change in ventilatory efficiency (VE/VCO2) slope at baseline and 3 months intervention
Change in workload maximal after 3 months Baseline and 3 months Change in workload max at baseline and 3 months intervention
Change in hand grip force after 3 months Baseline and 3 months Change in hand grip force on non dominant hand at baseline and 3 months intervention
Change in resting heart rate variability at rest after 3 months Baseline and 3 months Change in resting heart rate variability at baseline and 3 months intervention
Change 30 s sit-to-stand after 3 months Baseline and 3 months Change 30 s sit-to-stand at baseline and 3 months intervention
Change in Visceral adipose tissue after 3 months Baseline and 3 months Change in Visceral adipose tissue measure by Dual-energy X- ray absorptiometry (DEXA) at baseline and 3 months intervention
Change in isometric strength knee extensor after 3 months Baseline and 3 months Change in strength knee extensor (isometric) at baseline and 3 months intervention
Change in ventilation metaboreflex function after 3 months Baseline and 3 months Change in ventilation during metaboreflex test at baseline and 3 months intervention (Briefly, the subject is asked to exercise with the non-dominant arm by performing two 5 min handgrip manoeu- vres reaching approximately 50% of pre-determined maximal con- traction, in random order, separated by a 30 min interval: one bout with circulatory occlusion during the last 10 s of exercise and the all 3 min recovery phase ('clamp session'). During the clamp session, forearm cuff inflation to 30 mmHg above systolic blood pressure from the last 10 s of exercise till the end of the 3 min recovery phase; after cuff inflation, the subject is instructed to relax. Ergore- ceptor sensitivity is quantified as the percentage of the ventilatory and haemodynamic response to exercise maintained by circulatory occlusion during the third minute compared with the third minute of basal recovery.)
Change in diastolic blood pressure metaboreflex function after 3 months Baseline and 3 months Change in diastolic blood pressure during metaboreflex test at baseline and 3 months intervention
Change in heart rate at rest after 3 months Baseline and 3 months Change in heart rate at baseline and 3 months intervention
Change in 180°/sec strength knee extensor after 3 months Baseline and 3 months Change in strength knee extensor (180°/sec) at baseline and 3 months intervention
Change strength knee extensor in leg extension after 3 months Baseline and 3 months Change in one repetition maximal in leg extensor machine at baseline and 3 months intervention
Change in sub maximal strength knee extensor in leg extension after 3 months Baseline and 3 months Change in 10 repetitions maximal in leg extensor machine at baseline and 3 months intervention
Change in heart rate recovery after 3 months Baseline and 3 months Change in heart rate recovery at baseline and 3 months intervention
Trial Locations
- Locations (1)
Erasme Hospital
🇧🇪Brussels, Belgium