Intensity, Specificity and Reversibility of Inspiratory Muscle Training in Asthmatics

Not Applicable

Completed

• Conditions: Asthma
• Interventions: Device: High-intensity IMT; Device: Low-intensity IMT

• Registration Number: NCT02917824
• Lead Sponsor: Universidade Federal do Rio Grande do Norte

Brief Summary

Inspiratory muscle training (IMT) can reverse or delay the complications from the deterioration of inspiratory muscle function in asthma. Thus, the IMT has been considered a treatment option for people with asthma. The aim of this study is to investigate the training principles of intensity, specificity and reversibility of IMT in asthmatics.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-09-25
• Study First Submitted QC: 2016-09-26
• Study First Posted: 2016-09-28
• Study Start: 2016-11
• Primary Completion: 2017-03
• Study Completion: 2017-03
• Status Verified: 2019-09
• Last Update Submitted: 2019-09-06
• Last Update Posted: 2019-09-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 29

Inclusion Criteria

• Diagnosis of asthma
• Adults (18 - 60 years)

Exclusion Criteria

• Inability to perform the protocol established by the study
• Others respiratory diseases
• Request for study withdrawal

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High-intensity IMT	High-intensity IMT	Participants enrolled in this arm received high-intensity IMT
Low-intensity IMT	Low-intensity IMT	Participants enrolled in this arm received low-intensity IMT

Primary Outcome Measures

Name	Time	Method
Change in expiratory muscle strength	Baseline, 6 weeks later and 6 weeks after training	Maximal expiratory pressure
Change in inspiratory muscle strength	Baseline, 6 weeks later and 6 weeks after training	Maximal inspiratory pressure

Secondary Outcome Measures

Name	Time	Method
Change in six minute walk test distance	Baseline, 6 weeks later and 6 weeks after training	Six-minute walk test (6MWT)
Change in forced expiratory volume/forced vital capacity	Baseline, 6 weeks later and 6 weeks after training	Forced expiratory volume/forced vital capacity
Change in asthma control	Baseline, 6 weeks later and 6 weeks after training	Asthma Control Questionnaire measures the adequacy of asthma control and change in asthma control which occurs either spontaneously or as a result of treatment. Scores range between 0 (totally controlled) and 6 (severely uncontrolled)
Change in quality of life	Baseline, 6 weeks later and 6 weeks after training	Asthma Quality of Life Questionnaire is a disease-specific health-related quality of life instrument that taps both physical and emotional impact of disease. Scores range 1-7, with higher scores indicating better quality of life.
Change in forced vital capacity	Baseline, 6 weeks later and 6 weeks after training	Forced vital capacity in litres and % of predicted
Change in forced expiratory volume	Baseline, 6 weeks later and 6 weeks after training	Forced expiratory volume in litres and % of predicted
Change in inspiratory muscle activity	Baseline, 6 weeks later and 6 weeks after training	Surface electromyography of inspiratory muscles

Trial Locations

Locations (1)

Gardenia Maria Holanda Ferreira; 🇧🇷 Natal, Rio Grande Do Norte, Brazil