Effects of a Supervised Training Program on Functional Capacity in Patients With HFpEF and Chronotropic Incompetence
- Conditions
- Heart Failure With Preserved Ejection FractionChronotropic Incompetence
- Registration Number
- NCT05649787
- Lead Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria:<br><br> - Patients diagnosed with heart failure with preserved ejection fraction according to<br> 2021 ESC guidelines for Heart Failure.<br><br> - N-terminal pro-B-type natriuretic peptide (NT-proBNP) >125 pg/mL in the last month<br><br> - Stable symptomatic heart failure patients (New York Heart Association functional<br> class II-III/IV) during the last month<br><br> - Age = 60 years old.<br><br> - Blunted heart rate (HR) response during a maximal cardiopulmonary exercise testing<br> (CPET), defined as a chronotropic index <0.62 if previous treatment with<br> Beta-blockers or chronotropic index <0.80 in patients without beta-blockers.<br> Chronotropic index= [HRpeak exercise - HRrest] / [220 - age - HRrest]<br><br>Exclusion Criteria:<br><br> - Inability to perform a valid baseline cardiopulmonary exercise test<br><br> - Cardiac pacemaker<br><br> - Significant primary moderate-to-severe valve disease<br><br> - Effort angina or signs of ischemia during CPET<br><br> - Primary cardiomyopathies<br><br> - Cardiac transplantation<br><br> - Any other comorbidity with a life expectancy of less than one year
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Peak oxygen consumption
- Secondary Outcome Measures
Name Time Method Chronotropic response;Kansas City Cardiomyopathy Questionnaire Scales