Effect of beta-alanine supplementation on exercise capacity in people with type 2 diabetes

• Conditions: Type 2 Diabetes Mellitus; Obesity; Metabolic and Endocrine - Diabetes; Diet and Nutrition - Obesity

• Registration Number: ACTRN12613000273785
• Lead Sponsor: Southern Cross University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-03-06
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Male
• Target Recruitment: 40

Inclusion Criteria

Diagnosis of type 2 diabetes.
Medically stable and medically managed.
No documented cardiac history or stable cardiac history for previous 6 months.
No change in diabetes medications for previous two months.
Not currently taking exogenous insulin injections.
Signed consent from their general practitioner (GP) or specialist.

Exclusion Criteria

Diabetic complications which may be worsened by exercise.
Change in medications during previous 2 months.
Unstable cardiovascular disease, stroke, or other conditions which might be worsened by exercise.
Lower limb injuries or chronic limb impairment which may preclude completion of a treadmill protocol.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Exercise capacity as determined by an incremental treadmill protocol[Baseline and at 4 weeks]

Secondary Outcome Measures

Name	Time	Method
Insulin sensitivity: Determined from fasting glucose and insulin using the most recent HOMA2-IR calculator (version 2.2.2, Oxford University). [Baseline and at 4 weeks];Blood lipids (Total Cholesterol, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), Triglycerides (TG) to be determined via standard enzymatic methods. LDL mathematically determined as total cholesterol minus HDL minus (0.45 x TG).[Baseline and at 4 weeks];Haemodynamics (Heart rate (HR), cardiac rhythm, and Blood Pressure (BP)): Seated blood pressure measured in duplicate on the left arm after 5 minutes rest on a standard hospital-grade sphygmomanometer. Exercise HR and cardiac rhythm determined by electrocardiogram.[Baseline and at 4 weeks];Diabetes Quality of Life Questionnaire[Baseline and at 4 weeks]