Effects of beta-blockers on exercise performance in uncomplicated hypertension - ND

Conditions: MedDRA version: 14.0Level: PTClassification code 10015488Term: Essential hypertensionSystem Organ Class: 10047065 - Vascular disorders
on complicated arterial hypertension
Therapeutic area: Diseases [C] - Cardiovascular Diseases [C14]

Registration Number: EUCTR2009-011156-21-IT

Lead Sponsor: FONDAZIONE MONZINO CENTRO CARDIOLOGICO

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Authorised-recruitment may be ongoing or finished

Sex: All

Target Recruitment: 60

Inclusion Criteria

- patients with essential arterial hypertension (grade I and II)
- age 40-70 years
- ongoing efficacious anti-hypertensive treatment without beta blockers (PA < 130/85 mmHg)
Are the trial subjects under 18?
Number of subjects for this age range: 0
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

treatment with beta-blockers
COPD
controindications for the use of beta blockers
arterial hypertension resistant to treatment, malignant or non essential.

Study & Design

Study Type: Interventional clinical trial of medicinal product

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main Objective: Evaluation of peak VO2, maximal exercise capacity and tollerance in hypertensive patients with 2 treatments versus vasodilator drugs of routine treatment (ACE inhibitors, sartans, Calcium-antagonists, doxazosina).;Secondary Objective: Evaluation of the metabolic rate;Primary end point(s): difference in peak of VO2 (ml/Kg/min), exercise capacity and duration 10%

Secondary Outcome Measures