The effects of statins on exercise performance

Completed

Conditions: The effects of statins on exericse performance
the effects of statins on trainingresponse
10028302

Registration Number: NL-OMON45565

Lead Sponsor: Integrative fysiologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 72

Inclusion Criteria

o Age: 40-70 years old
o Current statin user (group 1-2) for at least 3 months
o Mentally able/ allowed to give informed consent

Exclusion Criteria

o Familial hypercholesterolemia
o History of a cardiovascular event within 1 year of study participation
o Known hereditary muscle defect
o known mitochondrial disease
o Diabetes mellitus
o Contraindication for maximal incremental exercise test
o Contraindication for muscle biopsy

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Aim 1a.<br /><br>Difference in training response between the 3 groups<br /><br>Training response is defined as:<br /><br>* change in aerobic fitness ( maximal incremental cycling test)<br /><br><br /><br>Aim 1b.<br /><br>* Exercise-induced change in mitochondrial mass and function<br /><br>* Exercise-induced change in substrate use</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Aim 2.<br /><br>* Exercise-induced change in muscle strength, contractile function and fatigue,<br /><br>mass (voluntary force: 1 repetition maximum; contractility and fatigue assessed<br /><br>by electrical stimulation; mass assessed by DEXA scan) (aim 2)<br /><br><br /><br>Aim 3.<br /><br>* Exercise-induced change in pain- and fatigue rating, and quality of life</p><br>