Effect of statin ingestion on muscle function at rest and following acute exercise in humans

Phase 4

• Conditions: Statin-induced myopathy; Other - Conditions of unknown or disputed aetiology (such as chronic fatigue syndrome/myalgic encephalomyelitis)

• Registration Number: ACTRN12608000423314
• Lead Sponsor: The University of Melbourne

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2008-08-25
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Male
• Target Recruitment: 24

Inclusion Criteria

Healthy males, (18-35yrs) normal renal, liver and thyroid function. no other mediciations for histories of diease.

Exclusion Criteria

abnormal renal, thyroid and liver function

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess disturbance in skeletal muscle mitochondrial function. Biochemical assays will be performed on muscle biopsy samples to analyse mitochondrial enzyme function and protein expression. Also signalling proteins and their gene transcripts will be measured to assess mitochondrial biogenesis.[4 weeks]

Secondary Outcome Measures

Name	Time	Method
Markers of mitochondrial biogenesis, including PGC-1 alpha, NFR-1, Tfam and AMPK will be assessed in muscle biopsy samples.[4 weeks]