The effects of cholesterol-lowering medication on skeletal muscle functioning
Recruiting
- Conditions
- Statin associated muscle symptomsmuscle functioning (contraction efficiency, muscle relaxation, muscle fatigue)whole body aerobic fitnessmitochondrial function
- Registration Number
- NL-OMON22168
- Lead Sponsor
- Radboud University Nijmegen Medical Centre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
oAge: 18-70 years old
oCurrent statin user (group 1-2) for at least 3 months
Exclusion Criteria
oFamilial hypercholesterolemia
oHistory of a cardiovascular event within 1 year of study participation
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method oEnergy generating capacity of muscle mitochondria (in muscle biopsy)<br /><br>oMuscle function (= muscle force, contractile speed, relaxation and fatigability) <br /><br>oCardiorespiratory fitness (incremental cycling test)<br>
- Secondary Outcome Measures
Name Time Method oMitochondrial number (in muscle biopsy)<br /><br>oBlood parameters: lipid profile (total cholesterol, HDL-, LDL-cholesterol, triglycerides), liver enzymes (ASAT, ALAT, gamma-GT), creatine kinase, pyruvate and lactate <br /><br>oStatin concentrations in the muscle and blood<br /><br>oQuestionnaires on muscle complaints (Short-form McGill pain questionnaire and Short-form Brief Pain Inventory)<br>