Effects of moderate intermittent hypoxia exposure on peripheral insulin sensitivity and substrate metabolism in humans - Moderate intermittent hypoxia exposure

niversiteit Maastricht0 sites15 target enrollmentStarted: TBDLast updated: June 11, 2024

Conditions

Trial Snapshot

No summary available.

•Males with overweight/obesity (body mass index >= 28 kg/m2) - insulin resistant (HOMA>=2.2) - Age: 30-65 - Non smoking - A stable bodyweight for at least 3 months (no change in bodyweight: <3kg)

•cardiovascular disease (determined by questionnaire, electrocardiogram (ECG), blood pressure (subjects with moderate to severe hypertension (grade 2 or 3 based on WHO criteria) will be excluded from participation in this study (SBP >160 mmHg, DBP > 100 mmHg)), type 2 diabetes mellitus, cancer, asthma or bronchitis, obstructive sleep apnea (OSAS), liver or kidney malfunction (determined based on ALAT and creatinine levels, respectively), disease with a life expectancy shorter then 5 years (subjects will be asked if they have a disease, which could lead to death within 5yr) diagnosis, abuse of products (alcohol consumption > 15 units/week), smoking, plans to lose weight (subjects will be asked if they have weight loss plans (e.g. to increase their physical activity level or change diet): a positive answer will lead to exclusion) or follow a hypocaloric diet, participation in organized sports activities more than three hours a week, use of high doses of anti-oxidant vitamins (A, C, E, β-carotene; a standard multi-vitamin capsule is permitted if less than 800µg/day Vit A, 60mg/day Vit C, 10mg/day Vit E and 400µg/day β-carotene) or use of any medication that influences glucose metabolism and inflammation

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