OLA to Lowest DP in Cardiac Surgery
Not Applicable
- Conditions
- Lung Collapse
- Interventions
- Procedure: DP-PEEPProcedure: RM-5
- Registration Number
- NCT03133754
- Lead Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
- Brief Summary
This study aims to compared the effects in driving pressure of an open-lung strategy with a positive end-expiratory pressure (PEEP) titrated to best driving pressure (DP) after a RM versus the recommended protective PEEP of 5 cmH2O without a recruitment manuever in non-obese patients undergoing cardiac surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- Non-obese patients scheduled for cardiac surgery (CABG and valve replacement)
Exclusion Criteria
- i) age <18yr or >80yr, ii) pregnancy or breast-feeding status, and iii) patients with previous known respiratory disease, iv) Body mass index >35 kg/m2, v) emergency surgery and vi) hemodynamic instability at entry (need of vasopressors or ionotropes at entry or a ventricular assist device.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description DP-PEEP DP-PEEP recruitment maneuver + individualized PEEP RM-5 RM-5 recruitment maneuver + fixed standard PEEP
- Primary Outcome Measures
Name Time Method driving pressure intraoperative The driving pressure is a physiological ventilatory parameter measured as platteau pressure minus PEEP. This parameter may be associated with postoperative pulmonary complications
- Secondary Outcome Measures
Name Time Method Postoperative pulmonary complications 72 first postoperative hours The most frequent postoperative pulmonary complications will be recorded (acute respiratory failure, pneumonia, atelectasis, need of ventilatory support, acute respiratory distress syndrome)
Trial Locations
- Locations (1)
Carlos Ferrando
🇪🇸Valencia, Spain