Measuring airway stiffness using optical imaging – a new tool to help understand lung diseases.

Not Applicable

Active, not recruiting

• Conditions: Chonic obstructive pulmonary disease; Asthma; Bronchiectasis; Respiratory - Chronic obstructive pulmonary disease; Respiratory - Asthma; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12607000624482
• Lead Sponsor: Sir Charles Gairdner Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-12-05
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Age >18yrs
Fit for bronchoscopy
Asthma or chronic obstructive pulmonary disease or bronchiectasis or healthy non-smoker

Exclusion Criteria

Age <18yrs
Unfit for bronchoscopy

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Compliance measurements of airway sizes ranging from small (3-4mm) to large (trachea). Comparisons between diseased and normal airways.[24 months]

Secondary Outcome Measures

Name	Time	Method
Comparisons of large airway compliance in healthy and abnormal lungs and their relationship to bronchomalacia and sputum retention. Compliance curves will be constructed by plotting the relationship between cross sectional area (as measured using OCT) and pressure (which will be applied via the anaesthetic circuit). The curves will be described in terms of absolute compliance (slope of the curve) and by applying the data to a mathematical exponential equation to derive the shape factor (Colebatch shape factor K).[24 months]