ABO-incompatible kidney transplantation in The Netherlands.
- Conditions
- kidney transplantation
- Registration Number
- NL-OMON27246
- Lead Sponsor
- There is no funding. This is a investigator-driven study.
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 10000
Inclusion Criteria
1. ABO-incomaptible and ABO-compatible kidney transplantations performed between March 2006 and January 2018.
2. CNI-based immunosuppresive therapy
Exclusion Criteria
1. unknown maintenance immunosuppresive therapy.
2. age <16 years
3. unknown ABO status
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome is (uncensored) graft survival of ABO-incompatible kidney transplant recipients as compared to ABO-compatible control patients with a living donor.
- Secondary Outcome Measures
Name Time Method Secondary outcomes include:<br>-Patient survival<br>-Renal function and proteinuria<br>-Infection<br>-Non-skin malignancy<br>-Renal allograft rejection<br>-Comparison with kidney transplant recipient with a postmortal allograft<br>-Comparison with kidney transplant recipients which an ABO-compatible donor via the national kidney exchange program<br>