Bacterial Translocation and intestinal permeability in patients undergoing open or laparoscopic total colectomy: open, right side or left side first laparoscopically
Completed
- Conditions
- Bacterial translocation and intestinal permeabilityInfections and InfestationsBacterial translocation
- Registration Number
- ISRCTN82467578
- Lead Sponsor
- Academic Medical Centre (AMC) (The Netherlands)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
1. Aged greater than 18 years
2. Patients planned for laparoscopic total colectomy for inflammatory bowel diseases or familial adenomatous polyposis or patients undergoing subtotal colectomy
3. Informed consent
Exclusion Criteria
1. Antibiotics within a week prior to surgery (perioperative antibiotics are allowed)
2. Use of probiotic products four weeks before or during the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Intestinal permeability, measured before, during and directely after surgery<br>2. Amount of bacterial translocation, measured before, during and directely after surgery
- Secondary Outcome Measures
Name Time Method o secondary outcome measures
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What are the molecular mechanisms of bacterial translocation in post-colectomy patients as studied in ISRCTN82467578?
How does laparoscopic total colectomy affect intestinal permeability compared to open surgery in the context of bacterial translocation?
What biomarkers correlate with increased risk of bacterial translocation following colectomy procedures in ISRCTN82467578?
Are there specific adverse events associated with laparoscopic approaches in colectomy that impact intestinal permeability?
What are the implications of findings from ISRCTN82467578 on current understanding of postoperative bacterial translocation management?