Comparison in myocardial perfusion between the intracoronary versus intralesional eptifibatide administration in acute myocardial infarctio

Phase 2

• Conditions: cardiovascular disease.; Certain current complications following acute myocardial infarction; I20-I25

• Registration Number: IRCT2016122722134N4
• Lead Sponsor: Vice Chancellor for research of Isfahan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Diagnosis of ST elevation myocardial infarction (STEMI) as defined by chest pain suggestive for myocardial ischemia for at least 30 minutes before hospital admission and symptoms onset time was less than 12 hours with 1 mm ST segment elevation in 2 or more contiguous leads (for V1-V3 ST elevation was 2 mm) simultaneously; These patients should also have three or more thrombus burden grade on the angiography. Thrombus burden was graded (G) as G0 = no thrombus, G1 = possible thrombus, G2 = small (greatest dimension = 1/2 vessel diameter), G3 = moderate (> 1/2 but < 2 vessel diameter), G4 = large (= 2 vessel diameter), G5 = unable to assess TB due to vessel occlusion; undergoing PCI; The consent of patients or their families to participate in the study; insensitivity to Eptifibatide
Exclusion criteria: Rescue PCI after thrombolytic therapy; Contraindications for antiplatelet such as bleeding disorder including gastrointestinal bleeding, hematuria, or known any bleeding tendency; thrombocytopenia (Platelet count<100.000/cm3); recent stroke (less than 6 months) and cardiogenic shock

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Thrombolysis in myocardial infarction (TIMI) flow. Timepoint: Before discharge, re hospitalization and after 6 month follow up. Method of measurement: TIMI flow grading.;Myocardial blush grade (MBG). Timepoint: Before discharge, re hospitalization and after 6 month follow up. Method of measurement: Myocardial blush grading.;No-reflow phenomenon. Timepoint: Before discharge, re hospitalization and after 6 month follow up. Method of measurement: TIMI flow grading and Myocardial blush grading.

Secondary Outcome Measures

Name	Time	Method
Re myocardial infarction. Timepoint: Before discharge, re hospitalization and after 6 month follow up. Method of measurement: ECG.;Heart failure. Timepoint: during hospitalization. Method of measurement: Eco cardiography.;Arrhythmia. Timepoint: Before discharge, re hospitalization and after 6 month follow up. Method of measurement: ECG.;Ventricular systolic function. Timepoint: Before discharge, re hospitalization and after 6 month follow up. Method of measurement: Eco cardiography.