Examination of Psychological and Physiological Pathways Linking Gratitude and Pain and the Moderating Effects of COMT Genotype on These Associations
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 145
- 试验地点
- 1
- 主要终点
- Change in Subjective Pain Ratings from Baseline to 10-minutes Post Cold Pressor Test
研究概览
简要总结
The goal of this clinical trial is to compare the effects of a brief gratitude intervention on individuals' psychological and physiological responses to acute pain. Furthermore, these associations will be examined in the context of genetic variations associated with both pain and psychological processes.
详细描述
After being informed about the study and potential risks, all patients giving written informed consent will be randomized to a behavioral writing intervention and a cold pressor task. Participants will be randomized to a gratitude or neutral writing condition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •must be pain-free
- •must be at least 18 years old
排除标准
- •cardiovascular disease
- •Raynaud's disease
- •being pregnant
- •having a current injury to or open cut or sore on one's non-dominant hand
- •history of fainting or seizures
- •history of frostbite in non-dominant hand
- •chronic pain conditions (e.g., fibromyalgia, neuropathy, arthritis)
- •malignant tumor
- •chronic lung disease
- •liver disease
- •kidney disease
- •gastrointestinal diseases
- •currently taking opioids
研究组 & 干预措施
Gratitude Writing
In the gratitude writing condition, participants will write continuously for 5 minutes about someone they are grateful for.
干预措施: Behavioral Writing Intervention (Behavioral)
Neutral Writing
Participants in the neutral writing condition will write continuously for 5 minutes about how they got to the research laboratory.
干预措施: Behavioral Writing Intervention (Behavioral)
结局指标
主要结局
Change in Subjective Pain Ratings from Baseline to 10-minutes Post Cold Pressor Test
时间窗: Baseline to 10 minutes post cold pressor test
Self-reported measures of pain will be reported on a numeric scale of 0 (no pain) to 10 (strongest pain imaginable every 15 seconds throughout a cold pressor test and again 1 minute and 10 minutes post cold pressor test.
Differences in Pain Tolerance to Cold Pressor Test
时间窗: Up to 1.5 minutes of Cold Pressor Test
Pain tolerance will be measured in terms of how many seconds individuals can keep their hand submerged in near-freezing water, for a maximum of up to 90 seconds (the task will be ended at that point).
Differences in Pain Onset to Cold Pressor Test
时间窗: Up to 1.5 minutes of Cold Pressor Test
Pain onset will be measured in seconds between participants submerging their hands into near-freezing water and the self-reported beginning of pain.
Change in Subjective Pain Ratings From Baseline to 10-minutes Post Cold Pressor Test
时间窗: Baseline to 10 minutes post cold pressor test
Self-reported measures of pain will be reported on a numeric scale of 0 (no pain) to 10 (strongest pain imaginable every 15 seconds throughout a cold pressor test and again 1 minute and 10 minutes post cold pressor test.
次要结局
- Differences in Autonomic Nervous System Responsivity(Baseline to 10 minutes post cold pressor test)
- Differences in Pain-Related Cognition(Immediately after the Cold Pressor Test)