Measuring the impact of extracorporeal carbon dioxide removal using PrismaLung on ventilator induced lung injury in mechanically ventilated patients

Peninsula Health0 个研究点目标入组 15 人开始时间: 2024年1月29日最近更新: 2024年2月5日

适应症

试验速览

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•1. Adult patients (18 years or older) with diagnosis of ARDS as per the Berlin Definition.(Ref Acute Respiratory Distress Syndrome: The Berlin Definition. JAMA. 2012; 307: 2526-33.)
•2. Driving pressure ( P) > 14 and/or Plateau >/= 25 (P is calculated using as plateau pressure minus positive end-expiratory pressure). (Ref: Combes A, Auzinger G, Capellier G, et al. ECCO2R therapy in the ICU: consensus of a European round table meeting. Critical Care. 2020; 24: 490)
•3. Respiratory rate > 20 breaths per minute
•4. pH < 7.25 and PaCO2 >45

•1. ARDS lasting more than 72 hours at the time of inclusion
•2. High pressure (Plateau pressure >30 cm H2O) or high FiO2 (>0·8) ventilation for more than 168 h (7 days);
•3. Severe hemodynamic instability as defined by ongoing arrhythmias that is not responsive to treatment
•4 Contraindication to limited anticoagulation
•5. Treatment limitation including not for resuscitation and not for reintubation
•6. Patients with potentially irreversible respiratory failure

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