Whole-Body MRA at 3T - A Comparison Between Two Different Scan Protocols

Completed

• Conditions: Atherosclerosis; Intermittent Claudication
• Interventions: Procedure: Whole body magnetic resonance angiography (WB-MRA)

• Registration Number: NCT00834548
• Lead Sponsor: Copenhagen University Hospital at Herlev

Brief Summary

To compare to different approaches in whole-body magnetic resonance angiography of patients suffering peripheral arterial disease.

Our hypothesis is that use of a new protocol improves the diagnostic quality of the WB-MRA procedure.

Detailed Description

Patients suffering peripheral arterial disease must undergo imaging procedures before endovascular or surgical procedures.

WB-MRA is an imaging procedure that can visualise the arterial system. WB-MRA can be performed in different manners. On option is to start the scan in the head region and continue down the body to the feet (standard protocol). Another option is to use a hybrid protocol that first examines the head and lower leg followed by examination of the pelvic and upper leg region.

A comparison between the standard and hybrid protocols has not been performed in a 3T high magnetic field system, therefore we will perform such a study.

Study Timeline

• Study Start: 2008-06
• Study Completion: 2008-08
• Study First Submitted: 2008-08-26
• Status Verified: 2009-02
• Study First Submitted QC: 2009-02-01
• Last Update Submitted: 2009-02-01
• Study First Posted: 2009-02-03
• Last Update Posted: 2009-02-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• Symptomatic lower extremity ischemia (claudication, ischemic wounds)
• Referred to digital subtraction angiography (DSA)

Exclusion Criteria

• Renal insufficiency (GFR < 30 ml/min)
• Contra-indications for MRI-examination (claustrophobia, metal-implants, pacemaker)
• Dementia
• Pregnancy/lactation
• Allergy to gadolinium based MRI contrast agents
• Acute disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
2	Whole body magnetic resonance angiography (WB-MRA)	WB-MRA hybrid protocol
1	Whole body magnetic resonance angiography (WB-MRA)	WB-MRA standard protocol

Primary Outcome Measures

Name	Time	Method
Diagnostic quality of WB-MRA

Secondary Outcome Measures

Name	Time	Method
Signal to noise ratio
Contrast to noise ratio

Trial Locations

Locations (1)

Copenhagen University Hospital Herlev; 🇩🇰 Herlev Copenhagen, Denmark