NCT04560647已完成不适用
Pilot Studies Testing Levels of P63 in Psoriasis Skin Lesions
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- Abnormal P63 signaling levels
研究概览
简要总结
The purpose of this study is to understand the role of a specific protein, tumor protein p63 in the skin disease psoriasis. This study is to further understand how psoriasis lesions happens. An understanding of key mediators that lead to psoriasis might aid in the discovery of more effective treatments for this skin disorder. This is not an intervention study. The study is looking to obtain currently untreated plaque psoriasis biopsies and also biopsies from non psoriasis patients. Psoriasis and medical history will be collected then skin biopsies will be obtained from the subjects.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Female and Male adult subjects age 18 to 50 with plaque psoriasis that is currently untreated (no topical agents for 2 weeks, no systemic agents for 1 month) or controls w/o psoriasis and no family history of psoriasis.
- •Must be able to give informed consent
- •All skin types on Fitzpatrick Scale (Type I-VI)
- •Able to provide medical history and list of medications for psoriasis and control subjects
排除标准
- •Underlying diseases that could affect wound healing (e.g., uncontrolled diabetes mellitus)
- •Tanning bed use within last 2 months
- •Photodynamic Therapy or UVB treatments in past 2 months
- •Female Subjects: pregnant or nursing
- •History of abnormal scarring (i.e., keloids)
- •Family history of psoriasis in first-degree relatives for control subjects
结局指标
主要结局
Abnormal P63 signaling levels
时间窗: Day 0
Determining if untreated psoriasis skin has abnormal p63 signaling
次要结局
未报告次要终点
研究者
研究点 (1)
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