A comparative clinical study to evaluate the efficacy of Mustadi Aasthapan Basti and Guduchiyadi Aasthapan Basti in the management of Kati-Prishtha-Trik Grah in Gambhir Vatrakta w.s.r. Ankylosing Spondylitis.

Ankylosing Spondylitis is characterized by chronic inflammatory arthritis predominantly affecting the sacroiliac joints and spine which can progress to bony fusion of the spine . Chronic back pain and progressive spinal stiffness are the most common features of the disease. Involvement of the spine and sacro-iliac joints, peripheral joints, digits, entheses are characteristics of the disease. Impaired spinal mobility, postural abnormalities, hip pain, peripheral arthritis, enthesitis, and dactylitis are all associated with ankylosing spondylitis. It is present in 1% to 6% of adults inheriting HLA B27, whereas the prevalence is 10% to 30% among HLA B27 positive adults. The onset is typically between the age of 20 to 30 years, with a male preponderance of about 3:1. The global prevalence is less than 0.5% in most populations2.There is no direct correlation of ankylosing spondylitis in ayurveda, However, on the basis of pathogenesis and symptoms ankylosing spondylitis can be correlated to kati-prishtha-trik grah of gambhir vatarakta. Sandhi shoth (jonit inflammation), dhah (joint warmth), stabdhta (joint stiffnes), kathinyata (limited joint movement), abhyantar sandhipeeda (joint tenderness), toda (thrombingpain) in kati (pelvic region), prishtha (posterior region of trunk from neck to pelvis) and trik pradesh (region around shoulder girdle) are the cardinal features of ankylosing spondylitis. In ayurveda, Grah (stiffness) is characteristics feature of vata and kapha dosha. Hence, In the treatment of kati-prishtha-trik grah in gambhir vatarakta (ankylosing spondylitis) primary concern should be effective treatment of kapha and vata dosha, which includes sequential administration of nadi swedan and basti. Basti is the best line of treatment in the management of aggravated vata dosha. Further mustadi aasthapan basti is specially indicated for vatarakta and guduchiyadi aasthapan basti is indicated for vataja vyadhi.

It will be Simple randomized parallel group clinical perspective study with each group 30 patients of Gambhir vatarakta will be selected for study.

The drugs will be prepared in the form of Kwatha for Aasthapana Basti and Murchita Tila Taila for Anuvasana Basti.

Duration of treatment - 16 days

Mode of Administration - Anorectal

Dose - 120 ml

Follow up - Follow up will be done on every 14th, 28th & 42nd day