Real-life and challenging gait skills to evaluate performance after cruciate-retaining total knee arthroplasy

Completed

Conditions: degenerative joint disease
Knee osteoarthritis
10005944

Registration Number: NL-OMON49702

Lead Sponsor: Sint Maartenskliniek

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 64

Inclusion Criteria

Patients undergoing total knee arthroplasty:
40-80 years old
Non-inflammatory knee osteoarthritis as indicated by radiology
Set to receive a primary total knee arthroplasty
In stable health

Healthy controls:
40-80 years old
In stable health

Exclusion Criteria

Patients undergoing total knee arthroplasty:
BMI > 35
Surgery to the study knee
Active infection, systemic infection
Trauma to study knee
Previous knee, hip, or ankle replacement surgery or planned to have one in the
next 24 months
Any musculoskeletal or neurological disease other than osteoarhritis that
impairs gait or balance
Severe damage to any knee ligament other than anterior cruciate ligament

Healthy controls:
Moderate to severe pain in one or both knees, hip or ankle (>4 on items 3-6
form Brief Pain Inventory)
Previous replacement surgery to knee, hip or ankle or planned for future
replacement surgery

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Difference between TKA-CR subjects 1 year post-operatively and healthy controls<br /><br>on average gait speed from gait bouts identified during 5-7 days continuous<br /><br>monitoring in real life (free-living).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Continous monitoring:<br /><br>- Quantity of gait bouts/hour<br /><br>- Peak turning velocity<br /><br>- Mean stride length<br /><br>- Mean stride time<br /><br>- Coefficient of variation of stride time<br /><br>- Asymmetry of step time<br /><br>- Coronal trunk range of motion<br /><br>- Foot strike angle<br /><br><br /><br>Challenging gait tasks:<br /><br>Peturbations:<br /><br>- Foot placement post-perturbation<br /><br>- CoM trajectory during the perturbation and subsequent steps<br /><br>- Margin of stability<br /><br>- CoP trajectory<br /><br>- Spatiotemporal gait parameters (step width, step length)<br /><br><br /><br>Up/downhill walking:<br /><br>- Sagittal knee moments<br /><br>- Knee adduction moments<br /><br>- Knee joint angles<br /><br>- Ankle joint moments and angles<br /><br>- Hip joint moments and angles<br /><br>- Toe-out angle<br /><br>- Toe-off angle<br /><br>- Spatiotemporal gait parameters</p><br>