Evaluation of Gas6 and Soluble MerTK Levels in Gingival Crevice Fluid in Individuals With Periodontal Health, Gingivitis, and Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Gas6 Levels in Gingival Crevicular Fluid
研究概览
简要总结
This study aimed to investigate gingival crevicular fluid (GCF) and serum soluble MerTK (sMerTK) and Gas6 levels in periodontal health and disease. A total of 90 individuals, 30 patients with stage III grade B periodontitis, 30 with gingivitis and 30 periodontally healthy individuals were included. Whole-mouth and site-specific clinical periodontal parameters including probing depth, clinical attachment level, bleeding on probing, gingival index, plaque index were recorded. GCF and serum sMerTK and Gas6 levels were measured by enzyme-linked immunosorbent assay. Statistical analysis was performed by using non-parametric tests.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Individuals without systemic diseases that may affect periodontal tissues (such as cardiovascular diseases, atherosclerosis, immune system disorders, rheumatoid arthritis, obesity, cancer, and diabetes)
- •Individuals who have not used antibiotics within the last 3 months
- •Individuals not taking any medications known to affect periodontal tissues
- •Individuals without infectious diseases such as HIV, hepatitis B virus (HBV), or tuberculosis
- •Individuals with at least 16 natural teeth, excluding third molars
- •Individuals aged 18 years and older
排除标准
- •Pregnant or lactating individuals
- •Individuals who have received periodontal treatment within the last 6 months
- •Current smokers
研究组 & 干预措施
periodontally healthy (H) group
干预措施: gingival crevicular fluid collection (Other)
gingivitis (G) group
干预措施: gingival crevicular fluid collection (Other)
stage III grade B periodontitis (P) group
干预措施: gingival crevicular fluid collection (Other)
结局指标
主要结局
Gas6 Levels in Gingival Crevicular Fluid
时间窗: baseline
Quantitative measurement of Gas6 levels (pg/mL) in gingival crevicular fluid samples using enzyme-linked immunosorbent assay (ELISA), and comparison of these levels among periodontally healthy, gingivitis, and periodontitis groups.
Soluble MerTK (sMerTK) Levels in Gingival Crevicular Fluid
时间窗: baseline
Quantitative measurement of soluble MerTK (sMerTK) levels (pg/mL) in gingival crevicular fluid samples using enzyme-linked immunosorbent assay (ELISA), and comparison of these levels among periodontally healthy, gingivitis, and periodontitis groups.
次要结局
- Plaque Index(baseline)
- Probing Depth(baseline)
- Clinical Attachment Loss(baseline)
- Gingival Index(baseline)
研究者
nuray Ercan
Assistant Professor
Abant Izzet Baysal University