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Clinical Trials/NCT07535177
NCT07535177RecruitingNot Applicable

Evaluation of Gas6 and Soluble MerTK Levels in Gingival Crevice Fluid in Individuals With Periodontal Health, Gingivitis, and Periodontitis

Abant Izzet Baysal University1 site in 1 country90 target enrollmentStarted: March 25, 2026Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Recruiting
Enrollment
90
Locations
1
Primary Endpoint
Gas6 Levels in Gingival Crevicular Fluid

Study Overview

Brief Summary

This study aimed to investigate gingival crevicular fluid (GCF) and serum soluble MerTK (sMerTK) and Gas6 levels in periodontal health and disease. A total of 90 individuals, 30 patients with stage III grade B periodontitis, 30 with gingivitis and 30 periodontally healthy individuals were included. Whole-mouth and site-specific clinical periodontal parameters including probing depth, clinical attachment level, bleeding on probing, gingival index, plaque index were recorded. GCF and serum sMerTK and Gas6 levels were measured by enzyme-linked immunosorbent assay. Statistical analysis was performed by using non-parametric tests.

Study Design

Study Type
Observational
Observational Model
Other
Time Perspective
Cross Sectional

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Individuals without systemic diseases that may affect periodontal tissues (such as cardiovascular diseases, atherosclerosis, immune system disorders, rheumatoid arthritis, obesity, cancer, and diabetes)
  • Individuals who have not used antibiotics within the last 3 months
  • Individuals not taking any medications known to affect periodontal tissues
  • Individuals without infectious diseases such as HIV, hepatitis B virus (HBV), or tuberculosis
  • Individuals with at least 16 natural teeth, excluding third molars
  • Individuals aged 18 years and older

Exclusion Criteria

  • Pregnant or lactating individuals
  • Individuals who have received periodontal treatment within the last 6 months
  • Current smokers

Arms & Interventions

periodontally healthy (H) group

Intervention: gingival crevicular fluid collection (Other)

gingivitis (G) group

Intervention: gingival crevicular fluid collection (Other)

stage III grade B periodontitis (P) group

Intervention: gingival crevicular fluid collection (Other)

Outcomes

Primary Outcomes

Gas6 Levels in Gingival Crevicular Fluid

Time Frame: baseline

Quantitative measurement of Gas6 levels (pg/mL) in gingival crevicular fluid samples using enzyme-linked immunosorbent assay (ELISA), and comparison of these levels among periodontally healthy, gingivitis, and periodontitis groups.

Soluble MerTK (sMerTK) Levels in Gingival Crevicular Fluid

Time Frame: baseline

Quantitative measurement of soluble MerTK (sMerTK) levels (pg/mL) in gingival crevicular fluid samples using enzyme-linked immunosorbent assay (ELISA), and comparison of these levels among periodontally healthy, gingivitis, and periodontitis groups.

Secondary Outcomes

  • Plaque Index(baseline)
  • Probing Depth(baseline)
  • Clinical Attachment Loss(baseline)
  • Gingival Index(baseline)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

nuray Ercan

Assistant Professor

Abant Izzet Baysal University

Study Sites (1)

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