Pneumological Acute Coronary Syndrom (ACS) Phenotyping Aachen

Completed

• Conditions: Acute Coronary Syndrom; Chronic Obstructive Pulmonary Syndrom

• Registration Number: NCT02587481
• Lead Sponsor: RWTH Aachen University

Brief Summary

In this open, monocentric, observational study acute coronary syndrom (ACS) patients will be characterized by pneumological examination concerning a concomitant chronic obstructive pulmonary disease (COPD). Often COPD coexists with ACS; therefore ACS patients benefit either from prevention or potential therapy of chronic hypoxia.

Detailed Description

In this study patients with either non ST-segment-elevation myocardial infarction (NSTEMI) or ST-segment-elevation myocardial infarction (STEMI) will be included. After amnesis patients will undergo blood withdrawal, blood-gas analysis and examinations concerning pulmonary function (Bodyplethysmography). In addition to routine blood withdrawal for differential blood count, 9 ml blood sample is takenfor molecular analysis of relevant prognostic chronic obstructive pulmonary disease (COPD)-blood based biomarkers, an for establishing a library of biomaterial in form of a biobank.

Study Timeline

• Study First Submitted: 2015-10-15
• Study First Submitted QC: 2015-10-23
• Study First Posted: 2015-10-27
• Study Start: 2015-11
• Primary Completion: 2017-05
• Study Completion: 2017-05
• Status Verified: 2017-11
• Last Update Submitted: 2017-11-17
• Last Update Posted: 2017-11-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Written declaration of consent
• Patients with acute myocardial infarct which can be either non ST-segment-elevation myocardial infarct (NSTEMI) or ST-segment-elevation myocardial infarct (STEMI), in both cases exaggeration of cardiac ischaemic markers

Exclusion Criteria

• Patients not fulfilling the incluson criterias or:
• Pregnant or breastfeeding women
• Participation in other studies
• Persons in depency from the sponsor or working with the sponsor
• Persons without mental ability or capacity to understand and follow the instructions of the investigator

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of patients with Acute Coronary Syndrom (ACS) and concomitant Chronic Obstructive Pulmonary Disease (COPD)	During 1-2 hours (at time of examination)

Secondary Outcome Measures

Name	Time	Method
Molecular analysis of relevant blood based chronic obstructive pulmonary disease (COPD) biomarkers	An average of 1 day

Trial Locations

Locations (1)

Amrei Pelzer; 🇩🇪 Aachen, NRW, Germany