The Predictive Value of Doppler Based Renal Ultrasound and Urinary Oxygen Tension for Prediction of Acute Kidney Injury After Open Heart Surgery

Recruiting

• Conditions: Doppler-Based Renal Ultrasound; Urinary Oxygen Tension; Acute Kidney Injury; Open Heart Surgery

• Registration Number: NCT07037485
• Lead Sponsor: Tanta University

Brief Summary

This study aims to investigate the predictive value of Doppler-based renal ultrasound and urinary oxygen tension in the development of acute kidney injury after cardiac surgery.

Detailed Description

Cardiac surgery-associated acute kidney injury (CSA-AKI) is a complication following cardiac surgery occurring in 15-30% of patients. It is associated with increased morbidity and mortality as well as prolonged hospital stay and higher medical costs.

The renal artery pulsatility index (RAPI), which is determined using Doppler measurements, has been reported to detect patients with a high risk of AKI. Additionally, the renal resistance index (RRI), measured by Doppler ultrasound, can accurately predict the occurrence of AKI.

Urinary oxygen partial pressure in the bladder has been shown to decrease in the setting of sepsis, reduced renal blood flow, and decreased cardiac output.

Study Timeline

• Study Start: 2024-10-01
• Status Verified: 2025-06
• Study First Submitted: 2025-06-17
• Study First Submitted QC: 2025-06-17
• Last Update Submitted: 2025-06-17
• Study First Posted: 2025-06-25
• Last Update Posted: 2025-06-25
• Primary Completion: 2026-09-01
• Study Completion: 2026-09-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Age above 21 years.
• Both sexes.
• Undergoing elective on-pump cardiac surgery.

Exclusion Criteria

• Patients with chronic kidney disease.
• Patients with any renal pathology or anatomic kidney abnormalities.
• Patients on renal replacement therapy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of cases developed acute kidney injury	7 days after the procedure	Number of cases developed acute kidney injury as defined by KIDGO guidelines (serum creatinine ≥ 0.3 mg/dL from base line within 48 hours, or ≥1.5 fold within 7 days, or urine output \<0.5 mL/kg/hour for six hours) in patients undergoing open heart surgery.

Secondary Outcome Measures

Name	Time	Method
Length of intensive care unit stay	7 days after the procedure	The length of stay in an Intensive Care Unit (ICU) is defined as the duration a patient spends in the ICU, typically measured from the time of admission to the ICU until the time of discharge.
Length of hospital stay	7 days after the procedure	Length of hospital stay will be measured from admission till discharge from hospital.
Need for renal replacement therapy	7 days after the procedure	Need for renal replacement therapy will be recorded.
Number of patients developed chronic kidney disease	7 days after the procedure	Number of patients developed chronic kidney disease will be recorded.
Mortality rate	7 days after the procedure	Mortality rate will be recorded.

Trial Locations

Locations (1)

Tanta University; 🇪🇬 Tanta, El-Gharbia, Egypt