A comparison of allogenic blood transfusion between acute normovolemic hemodilution and standard care in patient undergoing cardiac surgery: A prospective randomized controlled study
Phase 2
- Conditions
- umber of patients receiving transfusion of RBC during hospital stay between acute normovolemic hemodilution and standard care in cardiac surgery patientsAcute normovolemic hemodilution Cardiac surgery patients
- Registration Number
- TCTR20210218006
- Lead Sponsor
- Maharaj Nakorn Chiang Mai Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- nknown
- Sex
- All
- Target Recruitment
- 330
Inclusion Criteria
Aged > 18 years old
Signed informed consent
Any cardiac surgical intervention on CPB
Elective surgery
Exclusion Criteria
1. Medical decision
2. Unstable coronary artery disease
: Recent MI (<6wks)
: Unstable angina
: severe (>70%) LM coronary artery stenosis
3. Critical preoperative : Hb < 11 g/dL
: VT
: VF, aborted sudden cardiac death, preoperative cardiac massage
: Preoperative ventilation
: Hemodynamic instability
: Preoperative inotrope
: Preoperative IABP
: Preoperative LVAD
: Preoperative ECMO
: Preoperative severe acute renal failure
4. Emergency surgery
5. Pregnancy
6. Therapy with one of following at the time
of surgical intervention
: DAPT
: Antiplatelet drug (except ASA) : Heparin <6h
: Tirofiban <8h
: Bivalirudin <12h
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method umber of patients receiving transfusion of RBC during hospital stay During hospital stay until discharge Record patients data
- Secondary Outcome Measures
Name Time Method Bleeding complications Postoperative daily until discharge Amount of blood components transfuse, blood test, surgical revision for bleeding,Ischemic complications Postoperative daily until discharge MI, stroke, thromboembolic events,Acute kidney injury Postoperative daily 3 days Serum Creatinine