Bacteriological Study of Acute Follicular Tonsillitis
- Conditions
- Acute Follicular Tonsillitis
- Registration Number
- NCT04321733
- Lead Sponsor
- Assiut University
- Brief Summary
The objective of the study is to answer the following questions :-
1. Is there an actual failure rate in tonsillitis treatment with amoxicillin clavulanate ? If yes,
2. What is (are) the possible reason(s) to explain it in our locality ?
- Detailed Description
Tonsillitis is one of the most common diseases in the throat that occurs in the younger age group .
The predominant bacteria causing tonsillitis are group A b-haemolytic streptococci (GABHS), which are highly susceptible to the penicillin group of antibiotics.
It has been reported in the literature that the rate of penicillin failure has consistently increased from about 7% in the 1950s to almost 40% in the 2000s.
Authors propose many reasons to explain such failure rates e.g. the coexistence of oropharyngeal beta-lactamase producing bacteria .
Although there were no documented reports, it was observed that there are rising reports of failure in treatment of acute follicular tonsillitis by amoxicillin clavulanate.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 66
Not provided
- Other causes of tonsillitis that do not cause suppuration .
- Age below five , and above 60 years .
- Patients who received antibiotic one week before presentation .
- Immune compromised patients .
- Patients with quinsy.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The sensitivity of the isolated organism to amoxicillin clavulanate according to culture and sensitivity test Baseline throat swabs that will be taken from the tonsillar exudate, placed in sterile bottles and brought to the laboratory for Bacteriological culture of the organism and Antibiotic sensitivity tests will be done for the isolated organism(s).
- Secondary Outcome Measures
Name Time Method