The effects of collagen and hyaluronic acid for osteoarthritis symptoms study (CHAOS study), OCU-0704

Not Applicable

• Conditions: Osteoarthritis of the knee

• Registration Number: JPRN-UMIN000001027
• Lead Sponsor: Osaka City University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2008-02-23
• Study Completion: 2009-06-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Not provided

Exclusion Criteria

artificial replacement of the knees, current use of NSAIDs, current use of steroid, rheumatoid arthritis patients, severe inflammation (ESR>=40mm/h or RF positive), intraarticular injection to the knees within 3 months, abnormal function of liver and kidney (2.5 times or more normal value), intake of alternative medicine (glcosamin, chondroitin sulfate, collagen, and hyaluronic acid) within 4 weeks, remarkable obesity (BMI>30), pregnant or nursing

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
WOMAC score, joint narrowing of the knee (MTP view), SF-36, Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ)

Secondary Outcome Measures

Name	Time	Method
Bone metabolic marker (BAP, NTx), cartilage metabolic marker (COMP)