A Phase II Trial to Correlate Early Clinical Response to Pathologic Outcome With Neoadjuvant Systemic Therapy in Patients With Early Stage Breast Cancer
Overview
- Phase
- Phase 2
- Intervention
- Paclitaxel
- Conditions
- Breast Cancer
- Sponsor
- Baylor Breast Care Center
- Enrollment
- 185
- Locations
- 2
- Primary Endpoint
- Change in Clinical Tumor Measurement vs. Pathologic Response
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The purpose of this study is to learn whether clinical response (the amount a tumor shrinks based on imaging or tumor measurements obtained by physical exam) predicts pathologic response (the amount of tumor remaining when surgery is performed) in participants with breast cancer who are receiving chemotherapy prior to surgery.
Detailed Description
Neoadjuvant therapy was first introduced to improve surgical outcomes of breast cancer and to be able to assess the pathological responsiveness to therapy at the time of surgery. Over time, it became a useful experimental platform in clinical research in breast cancer, and in recent years became an important part of standard management of certain subtypes and clinical stages in breast cancer. It has been long established that patients who achieve pathologic complete response (pCR, i.e., the absence of any cancer in the tissue removed during surgery) after receiving neoadjuvant treatment have better outcomes than those who don't, especially in HER2+, and triple-negative breast cancer (TNBC). Many reports add aggressive ER+ breast cancer to these groups. So far, the only way to know whether a patient achieved pCR is to give them a full course of therapy and then proceed to surgery. One of the areas that has attracted significant research interest has been the effort to develop early predictors of pCR. This way, treatment can be tailored in the future to each patient and each tumor and can spare patients ineffective therapy. Some of these predictors include tissue biomarkers, blood based biomarkers, and imaging biomarkers. It has been observed in neoadjuvant clinical trials that many patients have an impressive early clinical response to treatment after 1-2 cycles of treatment. Anecdotally, many of those patients go on to have a pCR at the time of surgery. This observation, if validated in a prospective clinical trial, may lead to a simple, inexpensive way to assess tumor responsiveness and predict pCR using clinical exam and simple imaging. Using imaging or molecular changes to predict pCR will also be explored in this study. A consortium of investigators will be studying image analysis and proteogenomic changes early in the course of treatment to predict clinical response specifically in participants with TNBC. Only participants with TNBC will be required to undergo a research biopsy and research MRI prior to starting treatment, and again after the first cycle of treatment. The investigators therefore hypothesize that absence of early clinical response, defined as at least a 30% reduction in the size of the breast tumor by Day 21 of treatment (as measured by either imaging or clinical exam), will be associated with absence of pCR at the time of surgery, in 3 subtypes of breast cancer - TNBC, HER2+, high-risk ER+. All treatment in this study is standard of care (non-investigational).
Investigators
Mothaffar Rimawi
Professor
Baylor Breast Care Center
Eligibility Criteria
Inclusion Criteria
- •At least 18 years of age, and legally able to provide informed consent. Both men and women are eligible.
- •Histologically confirmed, invasive breast cancer. Tumor may be triple negative (as defined by ASCO-CAP guidelines), HER2-positive (as defined by ASCO-CAP guidelines), or high-risk estrogen receptor positive (as defined by ASCO-CAP guidelines).
- •To be considered "high risk," at least 2 of the following criteria must be met: 1) histologic grade 3; 2) patient age 50 or less; 3) ER Allred score \< 6; 4) Ki-67 ≥ 30%.
- •Tumors must be at least 2 cm by clinical exam or ultrasound
- •Bilateral breast cancers are allowed if the following criteria are met: 1) A lesion on one side (meeting the criteria above) is designated as the index lesion on which study assessments will be performed, and 2) the same treatment regimen is appropriate for both cancers as determined by the treating physician.
- •ECOG performance status of 0 or 1
- •Left ventricular ejection fraction (LVEF) ≥ the institutional lower limit of normal, as assessed by echocardiogram or Multigated Acquisition (MUGA )scan.
- •Adequate organ function, as determined by the following parameters:
- •Absolute Neutrophil Count (ANC) ≥ 1200/mm3
- •Platelets ≥ 100,000/mm3
Exclusion Criteria
- •Definitive clinical or radiologic evidence of Stage IV disease
- •Inflammatory breast cancer
- •Participants who are pregnant or lactating
- •History of an excisional biopsy or lumpectomy performed prior to study entry
- •Prior treatment with anthracyclines for any malignancy.
- •Prior treatment for currently diagnosed breast cancer (i.e., endocrine therapy, chemotherapy, targeted therapy, or radiation.
- •History of cardiac disease that would preclude the use of drugs included in these treatment regimens. This includes, but is not limited to:
- •Angina pectoris requiring the use of anti-anginal medication
- •Ventricular arrhythmias except for benign premature ventricular contractions
- •Supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication
Arms & Interventions
Triple Negative Breast Cancer (for tumors > 5 cm)
Paclitaxel IV plus carboplatin IV (+/- pembrolizumab IV) (4 cycles total), followed by doxorubicin IV plus cyclophosphamide IV (+/- pembrolizumab IV) (4 cycles total)
Intervention: Paclitaxel
Triple Negative Breast Cancer (for tumors > 5 cm)
Paclitaxel IV plus carboplatin IV (+/- pembrolizumab IV) (4 cycles total), followed by doxorubicin IV plus cyclophosphamide IV (+/- pembrolizumab IV) (4 cycles total)
Intervention: Carboplatin
Triple Negative Breast Cancer (for tumors > 5 cm)
Paclitaxel IV plus carboplatin IV (+/- pembrolizumab IV) (4 cycles total), followed by doxorubicin IV plus cyclophosphamide IV (+/- pembrolizumab IV) (4 cycles total)
Intervention: Doxorubicin
Triple Negative Breast Cancer (for tumors > 5 cm)
Paclitaxel IV plus carboplatin IV (+/- pembrolizumab IV) (4 cycles total), followed by doxorubicin IV plus cyclophosphamide IV (+/- pembrolizumab IV) (4 cycles total)
Intervention: Cyclophosphamide
Triple Negative Breast Cancer (for tumors > 5 cm)
Paclitaxel IV plus carboplatin IV (+/- pembrolizumab IV) (4 cycles total), followed by doxorubicin IV plus cyclophosphamide IV (+/- pembrolizumab IV) (4 cycles total)
Intervention: Pembrolizumab
Triple Negative Breast Cancer (for tumors < 5 cm)
Paclitaxel IV (4 cycles total), followed by doxorubicin IV plus cyclophosphamide IV (4 cycles total)
Intervention: Paclitaxel
Triple Negative Breast Cancer (for tumors < 5 cm)
Paclitaxel IV (4 cycles total), followed by doxorubicin IV plus cyclophosphamide IV (4 cycles total)
Intervention: Doxorubicin
Triple Negative Breast Cancer (for tumors < 5 cm)
Paclitaxel IV (4 cycles total), followed by doxorubicin IV plus cyclophosphamide IV (4 cycles total)
Intervention: Cyclophosphamide
HER2-Positive Breast Cancer
Paclitaxel IV plus Trastuzumab IV plus Pertuzumab IV (or PHESGO) (4 cycles total), followed by doxorubicin IV plus cyclophosphamide IV administered (4 cycles total)
Intervention: Paclitaxel
HER2-Positive Breast Cancer
Paclitaxel IV plus Trastuzumab IV plus Pertuzumab IV (or PHESGO) (4 cycles total), followed by doxorubicin IV plus cyclophosphamide IV administered (4 cycles total)
Intervention: Trastuzumab
HER2-Positive Breast Cancer
Paclitaxel IV plus Trastuzumab IV plus Pertuzumab IV (or PHESGO) (4 cycles total), followed by doxorubicin IV plus cyclophosphamide IV administered (4 cycles total)
Intervention: Pertuzumab
HER2-Positive Breast Cancer
Paclitaxel IV plus Trastuzumab IV plus Pertuzumab IV (or PHESGO) (4 cycles total), followed by doxorubicin IV plus cyclophosphamide IV administered (4 cycles total)
Intervention: Doxorubicin
HER2-Positive Breast Cancer
Paclitaxel IV plus Trastuzumab IV plus Pertuzumab IV (or PHESGO) (4 cycles total), followed by doxorubicin IV plus cyclophosphamide IV administered (4 cycles total)
Intervention: Cyclophosphamide
HER2-Positive Breast Cancer
Paclitaxel IV plus Trastuzumab IV plus Pertuzumab IV (or PHESGO) (4 cycles total), followed by doxorubicin IV plus cyclophosphamide IV administered (4 cycles total)
Intervention: Pertuzumab/Trastuzumab/Hyaluronidase-zzxf
Hormone Receptor Positive Breast Cancer
Paclitaxel IV plus Carboplatin IV (4 cycles total), followed by doxorubicin IV plus cyclophosphamide IV (4 cycles total)
Intervention: Paclitaxel
Hormone Receptor Positive Breast Cancer
Paclitaxel IV plus Carboplatin IV (4 cycles total), followed by doxorubicin IV plus cyclophosphamide IV (4 cycles total)
Intervention: Doxorubicin
Hormone Receptor Positive Breast Cancer
Paclitaxel IV plus Carboplatin IV (4 cycles total), followed by doxorubicin IV plus cyclophosphamide IV (4 cycles total)
Intervention: Cyclophosphamide
Outcomes
Primary Outcomes
Change in Clinical Tumor Measurement vs. Pathologic Response
Time Frame: Baseline and at surgery (after 20 weeks)
Clinical tumor measurements are tumor measurements obtain via imaging (mammogram or ultrasound) or by physical exam. Pathologic response is the amount of tumor remaining at the time of surgery, as determined by the pathologist.
Secondary Outcomes
- Pathologic Complete Response Rate in each Breast Cancer Subtype(20 weeks)
- Predictive value of clinical response following 1 cycle of chemotherapy to predict pathologic complete response(20 weeks)