Effect of Transcranial Direct Current Stimulation on the Voice
- Conditions
- Transcranial Direct Current StimulationVoice DisturbanceVoice and Resonance Disorders
- Interventions
- Device: Transcranial direct current stimulation
- Registration Number
- NCT06544122
- Lead Sponsor
- Universidade Federal de Pernambuco
- Brief Summary
The goal of this clinical trial is to verify the effect on the voice of transcranial direct current stimulation (tDCS) in vocally healthy non-singers. The main question it aims to answer is: What is the brain area in which tDCS promotes better vocal performance in vocally healthy individuals? Each participants received anodal tDCS applied at an intensity of 2 mA for a duration of 20 minutes for tDCS stimulations in different areas with a 7-day washout period between stimulations. Vocal assessments was conducted before and after the intervention. The targeted places were the primary motor cortex (M1), primary somatosensory cortex (S1), Cerebellum, and dorsolateral prefrontal cortex (DLPFC).
- Detailed Description
Recently, non-invasive brain stimulation (NIBS) techniques , including transcranial direct current stimulation (tDCS), have been employed to enhance vocal skills. tDCS can be used to temporarily and reversibly modulate brain functions and is an increasingly popular tool for investigating the relationships between the brain and behavior . The aim of the present study is investigate the effect of tDCS applied to different areas on the voice of vocally healthy non-singers. This is a randomized crossover clinical trial, approved by the Research Ethics Committee of the Federal University of Pernambuco, number 5,758,856. Vocally healthy people from the city of Recife and its Metropolitan Region, aged between 18 and 45 years, participated in the study.Each participant underwent four tDCS stimulations in different areas with a 7-day washout period between stimulations to study their vocal assessments before and after tDCS. The targeted places were the primary motor cortex (M1), primary somatosensory cortex (S1), Cerebellum, and dorsolateral prefrontal cortex (DLPFC). All participants were subjected to voice acessments analysis immediately before and after tDCS application in each area. Data normality will be analyzed using the Shapiro-Wilk test, rejecting the hypothesis of normal distribution when p\<0.05. ANOVA will be applied to design repeated measures in case of normality and in the existence of asymmetric data, Friedmann's ANOVA will be used for repeated measures. For the comparison of values before and after application of the technique and between modes of execution of the technique (with and without non-invasive neuromodulation), tests will be applied for related and independent samples, respectively, with a significance level of 5%
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 16
- Non-singers with healthy voice
- Smokers
- Those who present signs and symptoms of laryngeal, pharyngeal or respiratory diseases at the time of collection
- Volunteers who make regular use of neuroactive drugs
- Those who have metallic implants or a pacemaker
- People that have any history of seizures or epilepsy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Effects on voice of M1 tDCS in healthy voice volunteers Transcranial direct current stimulation The aim of this arm is to verify the effect on the voice of anodal tDCS M1 larynx target. Effects on voice of cerebellum tDCS in vocally health volunteers Transcranial direct current stimulation The aim of this arm is to verify the effect on the voice of anodal tDCS cerebellum target. Effects on voice of S1 tDCS in vocally health volunteers Transcranial direct current stimulation The aim of this arm is to verify the effect on the voice of anodal tDCS S1 larynx target. Effects on voice of PFDLC tDCS in vocally health volunteers Transcranial direct current stimulation The aim of this arm is to verify the effect on the voice of anodal tDCS PFDLC target.
- Primary Outcome Measures
Name Time Method Vocal range profile through study completion, an average of 6 months Min f0 (Hz) Max f0 (Hz) Ext f0 (Hz) Ext (ST) Mín int (dB) Max int (dB) Area (%)
Min f0 (Hz) Max f0 (Hz) Ext f0 (Hz) Ext (ST) Mín int (dB) Max int (dB) Area (%)
Minimum f0 (Hz); Maximum f0 (Hz); Extension f0; Extension in St; Minimum intensity (dB); Maximum intensity (dB); Area (%)
- Secondary Outcome Measures
Name Time Method Voice through study completion, an average of 6 months Jitter (%); Shimmer (%); Irregularity; GNE; DAI
Vocal effort through study completion, an average of 6 months The Adapted Borg CR10 for Vocal Effort Ratings (BR) maintained a scale from 0 to 10, where 0 means "no vocal effort at all", and 10 "maximum vocal effort". First, the participants have to reproduce a note played on a virtual keyboard (3 tones below their maximum glissando frequency) and sustain the note while counting from 21 to 30, immediately afterwards, the participants answered the Adapted Borg CR10 for Vocal Effort Ratings (BR).
Laryngeal diadochokinesis through study completion, an average of 6 months Change in the task of producing vowels separately, with rapid repetition of each vowel as quickly as possible for eight seconds
Trial Locations
- Locations (1)
Laboratório de Neurociência Aplicada
🇧🇷Recife, Pernambuco, Brazil