Effect of Different Desensitizing Protocols on the Pulp Inflammatory Response in Bleached Teeth: A Randomized Clinical Trial.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Pulp inflammation
研究概览
简要总结
This randomized, controlled, blinded clinical trial evaluated the effectiveness of different desensitizing protocols in preventing pulp inflammation after bleaching treatment with 35% hydrogen peroxide (PH) (Whiteness PH 35%).
详细描述
Thirty healthy third human molars extracted by orthodontic indication were randomized and allocated into five groups (n = 6): CN (negative control): without intervention; CP (Positive control): PH; PMB: PH + photobiomodulation with low power laser; CPP: PH + casein phosphopeptide phosphopeptide amorphous calcium phosphate (CPP-ACPF); NANO: PH + nanohydroxyapatite. The office whitening was performed in two sessions with a single application of 45 min and an interval of 48 hours between them. Pulp tissues were removed for immunohistochemical analysis. Immunostaining was performed for Caspase 3 using an Axio Scope.A1 microscope.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Sequential
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 26 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Lower third molars class I position A
- •Maxillary third molars horizontal position A
- •Absence of caries and enamel fracture
- •Absence of periodontal disease
- •Extraction of third molars for orthodontic reasons
- •No allergy to the anesthetic and positive pulp sensitivity test
排除标准
- •Calcification in the middle third of the root
- •Drug users or smokers
- •Patients who have already done whitening
- •Root apex with incomplete formation and patients with systemic problems that would make surgery impossible
研究组 & 干预措施
CPP Group
Whiteness HP 35% + CPP
干预措施: Whiteness HP 35% (Other)
CPP Group
Whiteness HP 35% + CPP
干预措施: Whiteness HP 35% + CPP (Other)
Positive Control Group
Whiteness HP 35%
干预措施: Whiteness HP 35% (Other)
Laser Group
Whiteness HP 35% + Laser
干预措施: Whiteness HP 35% (Other)
Laser Group
Whiteness HP 35% + Laser
干预措施: Whiteness HP 35% + LASER (Device)
Nano Group
Whiteness HP 35% + NANO
干预措施: Whiteness HP 35% (Other)
Nano Group
Whiteness HP 35% + NANO
干预措施: Whiteness HP 35% + NANO (Other)
Negative Control
Without intervention
结局指标
主要结局
Pulp inflammation
时间窗: 3 days After extraction of third molars
Evaluation of pulp inflammation through immunohistochemistry of the third molar whitening or not
次要结局
未报告次要终点
研究者
Cecy Martins Silva
Professor Clínico
Universidade Federal do Para