A Retrospective Study Exploring the Role of Serum Methylmalonic Acid (MMA) in Breast Cancer---focusing on Metastasis, Chemotherapy Resistance, and Ageing Effects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- KU Leuven
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- MMA levels
研究概览
简要总结
This project aims to investigate the role of MMA in breast cancer. To this end, we will measure MMA on serum samples collected at the time of breast cancer diagnosis, to investigate the role of MMA in predicting long-term recurrence risk, response to neoadjuvant chemotherapy, and its association with age and clinical frailty.
详细描述
This project aims to investigate the role of MMA in breast cancer. To this end, we will measure MMA on serum samples collected at the time of breast cancer diagnosis, to investigate the role of MMA in predicting long-term recurrence risk, response to neoadjuvant chemotherapy, and its association with age and clinical frailty. If the role of baseline serum MMA in therapy resistance and/or metastasis is confirmed, our study could be further extended by evaluating SOX4 expression in the tumor tissues (SOX4 is activated by MMA, and SOX4 induces EMT (epithelial to mesenchymal transition) and the metastasis process.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Female patients older than 18 years at diagnosis.
- •First diagnosis of invasive breast cancer.
- •All pathological parameters are available to identify histological subtype according to standard procedures.
- •Availability of frozen serum samples at diagnosis.
- •Voluntarily signed Informed Consent obtained before blood drawing for biobanking was performed.
排除标准
- •Pregnant at diagnosis.
- •stage 0 disease (in situ).
- •Bilateral BC at diagnosis or multifocal unilateral BC with different histology.
- •Other subtypes than Invasive ductal carcinoma.
- •Prior breast cancer.
结局指标
主要结局
MMA levels
时间窗: baseline
baseline serum MMA levels in pre-defined patients
次要结局
未报告次要终点