Comparing sedation effect of combination of ketamine with propofol and ketamine with dexmedetomidine in cases of upper GI endoscopy .
- Conditions
- Medical and Surgical,
- Registration Number
- CTRI/2025/05/086887
- Lead Sponsor
- Peoples College of medical science and research center
- Brief Summary
For this study elective patients for Upper GI endoscopy will be divided in 2 groups for procedural sedation .1 group will be receiving intravenous ketamine with propofol for sedation and the 2nd group will be receiving ketamine with dexmedetomidine for sedation .Both the groups will then be compared for haemodynamic changes - blood pressure and pulse and Ramsay sedation score and recovery time .ketamine will be the base drug and will be given in a dose of 1 mg/kg .propofol will be given in a dose of 1 mg/kg and a maintenance dose of 0.25 mg/kg while dexmedetomidine will be given in a dose of 0.5 mcg/ kg and a maintenance dose of 0.1 mcg/ kg .
In case adequate sedation is not achieved ketamine will be given in dose of 0.25 mg/ kg . Patients in both groups will also be assessed for recovery time along with Ramsay sedation score and haemodynamic changes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 60
American society of Anaesthesiologist grade 1, 2 and 3 Patients for elective UGI Endoscopy.
Patients not giving consent ASA grade more than 3 Patients with cardiac risk Patients with shock Patients with severe hepatorenal impairment.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood pressure variability 20 minutes
- Secondary Outcome Measures
Name Time Method Sedation 20 minutes
Trial Locations
- Locations (1)
Peoples Hospital
🇮🇳Bhopal, MADHYA PRADESH, India
Peoples Hospital🇮🇳Bhopal, MADHYA PRADESH, IndiaDr Catherine SinghPrincipal investigator09806543342drcatherinesingh@gmail.com