Evaluation of the Intracranial Volume Pressure Relationship in Increased Intracranial Pressure Patients by a Mathematic Manner
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Brain Injury
- Sponsor
- Chang Gung Memorial Hospital
- Enrollment
- 41
- Locations
- 1
- Primary Endpoint
- intracranial pressure
- Last Updated
- 15 years ago
Overview
Brief Summary
The purpose of this study is to discover a mathematic equation to express the intracranial pressure-volume (P-V) curve and a single indicator to reflect the status of the curve.
Detailed Description
Monitoring of intracranial pressure (ICP) has been used in the management of patients with increased ICP, or in whom increased ICP was suspected. ICP depends on the relative constancy of total volume inside the skull, comprising cerebrospinal fluid (CSF), blood, and brain tissue. The changes of CSF volume affect the ventricular fluid pressure and defined it as volume pressure response (VPR). The shape or curve of the intracranial volume-pressure (V-P) relationship is well known in daily neurosurgical practice. If the P-V curve can be expressed by mathematic manner, then there should be an indicator to reflect the status of the curve. This study is conducted in order to understand the difference of each P-V curve in patients with increased intracranial pressure. The individual VPR values have been tested with three mathematical models (linear, parabolic and exponential regression equation).
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients with severe brain damage
- •Underwent bilateral external ventricular drainage (EVD)
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
intracranial pressure
Time Frame: one minute.
The ICP values were obtained from the bedside ICU monitor. Once the ICP values exceed 20-25 mmHg, 1 ml of CSF was withdrawn from EVD and the corresponding change of ICP value was recorded. The withdrawn drainage of CSF continued until the final ICP value declined to 10 mmHg and the whole drainage procedure was completed within one minute.