High Concentration Oxygen in Neuromuscular Disease: Study 2

Not Applicable

Completed

• Conditions: euromuscular Disease; Kyphoscoliosis; Neuromuscular Disease; Neurological - Other neurological disorders; Musculoskeletal - Other muscular and skeletal disorders

• Registration Number: ACTRN12615000970549
• Lead Sponsor: Janine Pilcher

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-09-16
• Last Update Posted: 14 June 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Diagnosis of neuromuscular disease with a greater than or equal to 10% drop in vital capacity from standing to lying, or a sniff nasal inspiratory pressure under the lower limit (above which lie 95% of healthy subjects), based on work by Uldry and Fitting (Thorax 1995;50(4)).

OR

Kyphoscoliosis with an FVC <65% predicted.

Exclusion Criteria

Baseline transcutaneous carbon dioxide of greater than or equal to 60mmHg
Diagnosis of chronic obstructive pulmonary disease
FEV1:FVC ratio less than or equal to 70% (if participant able to perform forced spirometry)
Obesity (with a body mass index of greater than or equal to 40)
Any other condition which, at the investigator's discretion, is believed may present a safety risk or impact the feasibility of the study or the study results.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Transcutaneous carbon dioxide level, adjusted for baseline, as measured by a Sentec monitor. [30 minutes. ]