The effect of intensive blood glucose control with insulin on markers of short and medium term outcomes in patients hospitalised with acute exacerbations of chronic lung disease. Pilot Study to test feasibility and safety of a clinical protocol for intensive blood glucose control with insulin on medical wards - Pilot of Intensive Blood Glucose Control with Insulin on Medical Wards

Conditions: Acute exacerbations of chronic obstructive pulmonary disease. Stress hyperglycaemia. Insulin-induced hypoglycaemia. Cystic fibrosis
MedDRA version: 9.1Level: LLTClassification code 10010953Term: COPD exacerbation
MedDRA version: 9.1Level: LLTClassification code 10060439Term: Stress induced hyperglycaemia
MedDRA version: 9.1Level: LLTClassification code 10022484Term: Insulin hypoglycaemia
MedDRA version: 9.1Level: LLTClassification code 10011762Term: Cystic fibrosis

Registration Number: EUCTR2007-004956-35-GB

Lead Sponsor: St George's, University of London

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Recruiting

Sex: All

Target Recruitment: Not specified

Inclusion Criteria

- Physician diagnosis of AECOPD as primary reason for admission
- Able to enter study within 24 hours of admission
Cystic fibrosis
1) CF diagnosed by 2 of: clinical features, positive sweat test, genotype;
2) Current pulmonary exacerbation, at least 3 of: increased cough/sputum; fever; weight loss; absence from education/work due to illness; tachypnoea; new findings on chest examination; decreased exercise tolerance, decreased pulmonary function tests/oxyhaemoglobin saturation or new finding on chest radiograph [3],
3) >18 years
4) Admitted to hospital for intravenous antibiotics for pulmonary exacerbation.

Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

- Intensive care unit admission
- Moribund or not for active treatment
- Admission expected to last <48 hours
- Unable or unwilling to give informed consent
- Known Type I diabetes mellitus
- Level of English not sufficient to understand verbal and written information
- Patients with reduced awareness of hypoglycaemia including reduced Glasgow coma scale or those taking beta blockers
- Patients with renal or hepatic failure at increased risk of hypoglycaemia