Evaluating the Impact of Aerobic Exercise in Boys With Duchenne Muscular Dystrophy (DMD)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 43
- 试验地点
- 1
- 主要终点
- microRNA levels
研究概览
简要总结
This research study wants to learn more about Duchenne Muscular Dystrophy (DMD) and exercise. Today it is unknown how exercising impacts boys with DMD. The investigators believe that increasing activity and aerobic exercise may help with heart, lung, and muscle function. The investigators are hoping to compare physical strength and blood samples of boys with DMD to see if there are any differences between kids who exercised more as a child versus those who didn't.
详细描述
Recently, the American Academy of Neurology released new guidelines for children with Duchenne Muscular Dystrophy (DMD) with an updated recommendation to include moderate aerobic exercise. Historically, children with DMD were advised to not exercise as it was thought to accelerate muscle loss. Today, there is new data suggesting that moderate aerobic exercise that does not strain muscle may be beneficial and improve a child's quality of life with regard to heart disease, fatigue, and other factors of overall health. Although it is expected that children who exercise will experience health benefits, there is no scientific evidence indicating a positive or negative effect in a DMD population.
This study is trying to understand the role of aerobic exercise in boys with DMD and how it may impact heart, muscle, and lung function using newly identified biomarkers. The goal is to correlate increased aerobic exercise with improved functional outcomes and changes in biomarkers.
The data collected from this study will allow future development and implementation of an innovative and disease-specific home aerobic exercise program that in the future will be recommended to families of children with DMD.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 2 Years 至 17 Years（Child）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Ages 2-17 years old with a confirmed diagnosis of DMD. Has an appointment in MDA clinic at the Ann & Robert H. Lurie Children's Hospital of Chicago.
排除标准
- •Is less than two years old and does not have a confirmed diagnosis of DMD.
结局指标
主要结局
microRNA levels
时间窗: Baseline only
Understanding if there are any differences in microRNA's in boys who are more active versus those who are not.
次要结局
- Physical therapy assessment - North Star Ambulatory Assessment(Baseline only)
- Physical therapy assessment - 10 meter run test(Baseline only)
- Cardiac Assessments: Electrocardiogram (ECG)(Baseline only)
- Physical therapy assessment - time to standing from supine(Baseline only)
- Cardiac Assessments: Echocardiogram (ECHO)(Baseline only)
- Questionnaire: Pediatric Quality of Life: Neuromuscular module(Baseline only)
- Questionnaire: Physical Function Survey(Baseline only)
研究者
Aaron Zelikovich
Clinical Research
Ann & Robert H Lurie Children's Hospital of Chicago