NL-OMON48883
Recruiting
Not Applicable
Transjugular intrahepatic portosystemic shunt (TIPS): effect on pharmacokinetics - Effect of TIPS on pharmacokinetics
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cirrhosis
- Sponsor
- Academisch Medisch Centrum
- Enrollment
- 11
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Liver cirrhosis as documented by liver biopsy or elastography (e.g.
- •Fibroscan \> 15 kPa) in combination with usual radiological and biochemical
- •2\. Age \> 18 years.
- •3\. Elective indication for TIPS (recurrent tense ascites, recurrent/refractory
- •hepatic hydrothorax, or (recurrent) oesophageal or gastric bleeding treated
- •with endoscopic band ligation (EBL) or endoscopic injection sclerotherapy (EIS)
- •more than 2 weeks prior to screening.
- •4\. Signed informed consent
Exclusion Criteria
- •Absolute contraindications for TIPS placement
- •Child\-Pugh score \>\= 10
- •MELD score \> 20
- •Serum bilirubin 51 \> µmol/L
- •INR \> 1\.7
- •Serum creatinine \> 185 µmol/L
- •Active drug abuse or alcoholism
- •Overt neurologic disease
Outcomes
Primary Outcomes
Not specified
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