Volume-targeted Versus Pressure-limited Noninvasive Ventilation in Patients With Acute Hypercapnic Respiratory Failure
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Acute Hypercapnic Respiratory Failure
- Sponsor
- Beijing Chao Yang Hospital
- Enrollment
- 58
- Locations
- 1
- Primary Endpoint
- The decrease of arterial partial pressure of carbon dioxide (PaCO2) values from baseline to 6 hours after randomization
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Volume-targeted noninvasive ventilation (VT-NIV), a hybrid mode that targets a preseted tidal volume (VT) by automated adjustment of pressure support, could guarantee the delivered VT over pressure-limited noninvasive ventilation (PL-NIV) with fixed level pressure support. Whether VT-NIV is more effective in improving gas exchange in patients with acute hypercapnic respiratory failure (AHRF) as compared with PL-NIV remains unclear. Our aim was to verify whether in comparison with PL-NIV, use of VT-NIV was more effective in correcting hypercapnia, hence reducing the need for intubation and improving survival in patients with AHRF.
Investigators
Zujin Luo
Attending physician
Beijing Chao Yang Hospital
Eligibility Criteria
Inclusion Criteria
- •acute hypercapnic respiratory failure (AHRF)
- •arterial pH \<7.35 and ≥7.25
- •PaCO2 \>45 mmHg
Exclusion Criteria
- •age \<18 years
- •excessive amount of respiratory secretions or weak cough
- •upper airway obstruction
- •recent oral, facial or cranial trauma or surgery
- •recent gastric or esophageal surgery
- •severe metabolic acidosis; severe abdominal distension
- •cardiac or respiratory arrest
- •PaO2/FiO2 \<150 mmHg
- •pneumothorax
- •severe ventricular arrhythmia or myocardial ischemia
Outcomes
Primary Outcomes
The decrease of arterial partial pressure of carbon dioxide (PaCO2) values from baseline to 6 hours after randomization
Time Frame: 6 hours after randomization
PaCO2 value at baseline minus PaCO2 value at 6 hours after randomization