Volume-targeted Versus Pressure-limited Noninvasive Ventilation in Patients With Acute Hypercapnic Respiratory Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 58
- 试验地点
- 1
- 主要终点
- The decrease of arterial partial pressure of carbon dioxide (PaCO2) values from baseline to 6 hours after randomization
研究概览
简要总结
Volume-targeted noninvasive ventilation (VT-NIV), a hybrid mode that targets a preseted tidal volume (VT) by automated adjustment of pressure support, could guarantee the delivered VT over pressure-limited noninvasive ventilation (PL-NIV) with fixed level pressure support. Whether VT-NIV is more effective in improving gas exchange in patients with acute hypercapnic respiratory failure (AHRF) as compared with PL-NIV remains unclear. Our aim was to verify whether in comparison with PL-NIV, use of VT-NIV was more effective in correcting hypercapnia, hence reducing the need for intubation and improving survival in patients with AHRF.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •acute hypercapnic respiratory failure (AHRF)
- •arterial pH <7.35 and ≥7.25
- •PaCO2 >45 mmHg
排除标准
- •age <18 years
- •excessive amount of respiratory secretions or weak cough
- •upper airway obstruction
- •recent oral, facial or cranial trauma or surgery
- •recent gastric or esophageal surgery
- •severe metabolic acidosis; severe abdominal distension
- •cardiac or respiratory arrest
- •PaO2/FiO2 <150 mmHg
- •pneumothorax
- •severe ventricular arrhythmia or myocardial ischemia
- •severe hemodynamic instability despite fluid repletion and use of vasoactive agents
- •active upper gastrointestinal bleeding
- •lack of cooperation
- •refusal to receive NIV
结局指标
主要结局
The decrease of arterial partial pressure of carbon dioxide (PaCO2) values from baseline to 6 hours after randomization
时间窗: 6 hours after randomization
PaCO2 value at baseline minus PaCO2 value at 6 hours after randomization
次要结局
未报告次要终点
研究者
Zujin Luo
Attending physician
Beijing Chao Yang Hospital