The effect of Calcium Hydroxide, Triple Antibiotic Paste and Chlorhexidine on pain in teeth with Symptomatic Apical Periodontitis

Phase 4

Completed

• Conditions: Symptomatic Apical Periodontitis; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12622001513707
• Lead Sponsor: Qassim University

Brief Summary

The research question was '' Which of the following three drugs, triantibiotic paste, Calcium hydroxide paste and Chlorhexidine gels, has/have an effect on the pain of the tooth after the cleaning of the tooth root canal. A total of 100 patients were initially evaluated for eligibility. Twelve patients were excluded from the study as they were not meeting the inclusion criteria. However, eight of the patients refused to participate in the study. Hence, total eighty patients were included in the study. The patients were randomly divided into four groups according to random number table. Group 1 was named as Ca (OH)2, Group 2 as Chlorhexidine, Group 3 as Tri antibiotic paste and Group 4 as Control Group. The mean age of the patients was 30+2.34 years. The average pain scores were recorded and tabulated for all four groups at 4hrs, 48hrs, 72hrs and 96hrs. The Tri-antibiotic Paste was found to be most effective in achieving the post operative pain control. Further investigation is required to find out the exact mechanism by which TAP affects the individuals pain response.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2022-05-04
• Study Start: 2022-12-06
• Last Update Posted: 9 January 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

The inclusion criteria were single rooted teeth (anterior and posterior) with symptomatic apical periodontitis and negative response to vitality testing indicating necrotic pulp

Exclusion Criteria

non-restorable teeth and teeth having endo-perio lesions, acute or chronic apical abscess, chronic periodontitis or anatomical difficulties like open apices, calcified canals, severe dilacerations, internal/ external root resorption and occlusal interferences were excluded from the study. Additionally, allergic patients, patients taking medicines that could influence pain perception or having serious medical illness, systemic disorders, or immunocompromised diseases like AIDS, HBV were also excluded

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Post-root canal preparation pain assessed using the Wong-Baker’s FACES Pain Rating Scale[at 0, 4, 48 (Primary end point), 72, 96 hours, postoperatively]

Secondary Outcome Measures

Name	Time	Method
il[Nil]