Acute and long term effects of thyroid hormone replacement therapy in patients with ST-Elevation Myocardial Infarction (STEMI) and borderline/reduced triiodothyronine levels. - THIRST

OSPEDALE G.PASQUINUCCI-FONDAZIONE TOSCANA GABRIELE MONASTERIO/CNR0 个研究点开始时间: 2009年3月12日最近更新: 2012年3月19日

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•Male and female patients, all ethnic races, admitted to the Coronary Care Unit for chest pain and subsequently proven STEMI (ST Elevation Myocardial Infarction); Age between 30 to 70 years; Patients subjected to coronary revascularization through PTCA and stenting PTCA performed within 12 hours from the onset of symptoms Evidence of fT3 levels below the lower referral limit (<2.2 pg/mL for our laboratory) or decrease in fT3 plasma levels major than 20% with respect to the admission levels Signature of a written informed consent before randomization
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•Previous myocardial infarction Previous evidence of compromised left ventricular function (Ejection Fraction< 40%) Hemodynamic instability, cardiogenic shock, decompensated heart failure (NYHA IV class) at admission Use of inotropic drugs Thyroid disease Patients assuming: TH replacemement therapy, anti-thyroid drugs, corticosteroids, amiodarone, oral anticoagulant therapy, oral contraceptives Patients presenting atrial fibrillation or with previous documentation of paroximal or persistent atrial fibrillation Pregnant or breast-feeding women Sever systemic diseases including: neoplasia, decompensated diabetes mellitus with glicosilated haemoglobin levels major than 9%, liver cirrhosis, chronic obstructive lung disease with moderate to severe respiratory impairment, chronic kidney failure with creatinine plasma levels major than 3 mg/dL Systemic inflammatory/ autoimmune disease Patients holding mechanical cardiac valves, pace-makers or infusion pumps, magnetic materials like metallic clips and prothesis Patients allergic to synthetic thyroid hormone or any eccipient in the drug eventually administered Patients refusing or unable to supply written informed consent.

发起方

OSPEDALE G.PASQUINUCCI-FONDAZIONE TOSCANA GABRIELE MONASTERIO/CNR