Multimodal effects of Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism* a randomised placebo controlled Trial - TRUST

eids Universitair Medisch Centrum0 个研究点目标入组 188 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•-Community-dwelling patients aged 65 years and over with subclinical hypothyroidism.
•-Subclinical hypothyroidism is defined as persistently elevated TSH levels (><=4.6 and *19.9 mU/L) and free thyroxine (fT4) in reference range measured on a minimum of two occasions at least 3 months apart.

•-Subjects currently on Levothyroxine, antithyroid drugs, amiodarone or lithium.
•-Recent thyroid surgery or radio-iodine therapy (within 12 months).
•-Grade IV NYHA heart failure.
•-Prior clinical diagnosis of dementia.
•-Recent hospitalisation for major illness or elective surgery (within 4 weeks).
•-Recent acute coronary syndrome, including myocardial infarction or unstable angina (within 4 weeks).
•-Acute myocarditis or acute pancarditis
•-Untreated adrenal insufficiency and adrenal disorder
•-Terminal illness.
•-Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption
•-Subjects who are participating in ongoing RCTs of therapeutic interventions (including clinical trials of investigational medicinal products [CTIMPs])
•-Plan to move out of the region in which the trial is being conducted within the next 2 years (proposed minimum follow-up period).

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