Effect of Aerobic Exercise on Polycystic Ovary Syndrome

Not Applicable

Completed

• Conditions: Polycystic Ovary Syndrome
• Interventions: Other: Aerobic exercise in addition to Metformin treatment

• Registration Number: NCT05233514
• Lead Sponsor: Cairo University

Brief Summary

The development of Polycystic Ovary Syndrome has been linked to chronic low-grade inflammation (PCOS). In this context, the current study looked into the effects of aerobic exercise on IL6, TNF, and C-reactive protein (CRP) in PCOS women. This was a randomized clinical trial including 40 females diagnosed with PCOS who were between the ages of 25 and 35. The participants were divided into two groups, each with an equal number of individuals: aerobic exercise (AEM) and Metformin (M). At baseline and after 12 weeks of intervention, participants' levels of IL6, TNF, and CRP were measured.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-04-01
• Primary Completion: 2021-10-01
• Study Completion: 2021-12-10
• Study First Submitted: 2022-01-29
• Status Verified: 2022-02
• Study First Submitted QC: 2022-02-09
• Last Update Submitted: 2022-02-09
• Study First Posted: 2022-02-10
• Last Update Posted: 2022-02-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 40

Inclusion Criteria

• Mean age of 26.7 ± 2.3, body mass index (BMI) 23.6±3.5 kg/m2) .
• confirmation by medical history of hyperandrogenic oligo amenorrhea (<8 menses per year)
• PCO on ultrasonography of more than 10 ovarian follicles 2-9 mm in diameter

Exclusion Criteria

• Disorders known to cause hyperandrogenisms, such as congenital adrenal hyperplasia, thyroid dysfunction, and hyperprolactinemia.
• Renal or hepatic dysfunction

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Aerobic exercise group (AEM)	Aerobic exercise in addition to Metformin treatment	The AEM group performed aerobic exercise three times a week for 12 weeks in addition to Metformin treatment.
Metformin group (M)	Aerobic exercise in addition to Metformin treatment	The M group received Metformin only

Primary Outcome Measures

Name	Time	Method
Level of TNF-α	12 weeks
level of C- reactive protein	12 weeks
Level of Interleukin 6	12 weeks

Trial Locations

Locations (1)

Marwa Eid; 🇪🇬 Cairo, Egypt