nderstanding the role of tissue Fibrosis in Insulin Resistance associated with Polycystic Ovary Syndrome (PCOS) and the impact of Exercise: The FIREx study using a cohort and randomized control trial in women with and without PCOS.
- Conditions
- Polycystic Ovary SyndromeObesityInsulin ResistanceMetabolic and Endocrine - DiabetesPhysical Medicine / Rehabilitation - Other physical medicine / rehabilitationReproductive Health and Childbirth - Menstruation and menopauseDiet and Nutrition - ObesityRenal and Urogenital - Other renal and urogenital disorders
- Registration Number
- ACTRN12619000264189
- Lead Sponsor
- igel Stepto
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 101
Women with PCOS:
Premenopausal women aged between 18-45 with PCOS. PCOS will be diagnosed by Rotterdam Criteria which requires two of the following (after exclusion of other causes of hyperandrogenism):
1.Oligoovulation (irregular ovulation) or anovulation (lack of ovulation)
2.Clinical and/or signs of hyperandrogenism,
3.Polycystic ovaries on ultrasound and.
Women without PCOS (Control women):
Premenopausal women aged between 18-45 without PCOS, will be defined by having no Rotterdam features.
1.Current Smoker
2.Pregnancy
3.Known cardiovascular or respiratory conditions (e.g. asthma, cardiac arrhythmias),
4.Hypertension (resting blood pressure >160/105)
5.Bleeding disorders
6.Eating disorders
7.Skin or anaesthetic allergies,
8.Musculoskeletal injuries that may be aggravated by exercise,
9.Type 1 or 2 diabetes
10.Currently taken medication including:
a.Antihypertensives
b.insulin sensitisers (metformin),
c.anti-obesity drugs
d.hormonal contraceptives (pill, subdermal)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method